Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023604714> ?p ?o ?g. }
- W2023604714 endingPage "e1001249" @default.
- W2023604714 startingPage "e1001249" @default.
- W2023604714 abstract "The initial step in target cell infection by human, and the closely related simian immunodeficiency viruses (HIV and SIV, respectively) occurs with the binding of trimeric envelope glycoproteins (Env), composed of heterodimers of the viral transmembrane glycoprotein (gp41) and surface glycoprotein (gp120) to target T-cells. Knowledge of the molecular structure of trimeric Env on intact viruses is important both for understanding the molecular mechanisms underlying virus-cell interactions and for the design of effective immunogen-based vaccines to combat HIV/AIDS. Previous analyses of intact HIV-1 BaL virions have already resulted in structures of trimeric Env in unliganded and CD4-liganded states at ∼20 Å resolution. Here, we show that the molecular architectures of trimeric Env from SIVmneE11S, SIVmac239 and HIV-1 R3A strains are closely comparable to that previously determined for HIV-1 BaL, with the V1 and V2 variable loops located at the apex of the spike, close to the contact zone between virus and cell. The location of the V1/V2 loops in trimeric Env was definitively confirmed by structural analysis of HIV-1 R3A virions engineered to express Env with deletion of these loops. Strikingly, in SIV CP-MAC, a CD4-independent strain, trimeric Env is in a constitutively “open” conformation with gp120 trimers splayed out in a conformation similar to that seen for HIV-1 BaL Env when it is complexed with sCD4 and the CD4i antibody 17b. Our findings suggest a structural explanation for the molecular mechanism of CD4-independent viral entry and further establish that cryo-electron tomography can be used to discover distinct, functionally relevant quaternary structures of Env displayed on intact viruses." @default.
- W2023604714 created "2016-06-24" @default.
- W2023604714 creator A5016563724 @default.
- W2023604714 creator A5022372210 @default.
- W2023604714 creator A5022569819 @default.
- W2023604714 creator A5026405170 @default.
- W2023604714 creator A5038092347 @default.
- W2023604714 creator A5041098204 @default.
- W2023604714 creator A5042412445 @default.
- W2023604714 creator A5043225490 @default.
- W2023604714 creator A5053547210 @default.
- W2023604714 creator A5074792801 @default.
- W2023604714 creator A5005588614 @default.
- W2023604714 date "2010-12-23" @default.
- W2023604714 modified "2023-10-16" @default.
- W2023604714 title "Molecular Architectures of Trimeric SIV and HIV-1 Envelope Glycoproteins on Intact Viruses: Strain-Dependent Variation in Quaternary Structure" @default.
- W2023604714 cites W1589337577 @default.
- W2023604714 cites W1884404343 @default.
- W2023604714 cites W1970563411 @default.
- W2023604714 cites W1978434560 @default.
- W2023604714 cites W1991112092 @default.
- W2023604714 cites W1995355944 @default.
- W2023604714 cites W1998987175 @default.
- W2023604714 cites W1999053028 @default.
- W2023604714 cites W2010521915 @default.
- W2023604714 cites W2011084662 @default.
- W2023604714 cites W2018930937 @default.
- W2023604714 cites W2022086754 @default.
- W2023604714 cites W2023721493 @default.
- W2023604714 cites W2029101220 @default.
- W2023604714 cites W2046372454 @default.
- W2023604714 cites W2054520331 @default.
- W2023604714 cites W2062204035 @default.
- W2023604714 cites W2075416959 @default.
- W2023604714 cites W2080089116 @default.
- W2023604714 cites W2093395175 @default.
- W2023604714 cites W2094158458 @default.
- W2023604714 cites W2097074610 @default.
- W2023604714 cites W2098781795 @default.
- W2023604714 cites W2099308199 @default.
- W2023604714 cites W2099749788 @default.
- W2023604714 cites W2113282092 @default.
- W2023604714 cites W2114094228 @default.
- W2023604714 cites W2122151115 @default.
- W2023604714 cites W2127334055 @default.
- W2023604714 cites W2131317050 @default.
- W2023604714 cites W2131903471 @default.
- W2023604714 cites W2132629607 @default.
- W2023604714 cites W2137162710 @default.
- W2023604714 cites W2157615131 @default.
- W2023604714 doi "https://doi.org/10.1371/journal.ppat.1001249" @default.
- W2023604714 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3009598" @default.
- W2023604714 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21203482" @default.
- W2023604714 hasPublicationYear "2010" @default.
- W2023604714 type Work @default.
- W2023604714 sameAs 2023604714 @default.
- W2023604714 citedByCount "164" @default.
- W2023604714 countsByYear W20236047142012 @default.
- W2023604714 countsByYear W20236047142013 @default.
- W2023604714 countsByYear W20236047142014 @default.
- W2023604714 countsByYear W20236047142015 @default.
- W2023604714 countsByYear W20236047142016 @default.
- W2023604714 countsByYear W20236047142017 @default.
- W2023604714 countsByYear W20236047142018 @default.
- W2023604714 countsByYear W20236047142019 @default.
- W2023604714 countsByYear W20236047142020 @default.
- W2023604714 countsByYear W20236047142021 @default.
- W2023604714 countsByYear W20236047142022 @default.
- W2023604714 crossrefType "journal-article" @default.
- W2023604714 hasAuthorship W2023604714A5005588614 @default.
- W2023604714 hasAuthorship W2023604714A5016563724 @default.
- W2023604714 hasAuthorship W2023604714A5022372210 @default.
- W2023604714 hasAuthorship W2023604714A5022569819 @default.
- W2023604714 hasAuthorship W2023604714A5026405170 @default.
- W2023604714 hasAuthorship W2023604714A5038092347 @default.
- W2023604714 hasAuthorship W2023604714A5041098204 @default.
- W2023604714 hasAuthorship W2023604714A5042412445 @default.
- W2023604714 hasAuthorship W2023604714A5043225490 @default.
- W2023604714 hasAuthorship W2023604714A5053547210 @default.
- W2023604714 hasAuthorship W2023604714A5074792801 @default.
- W2023604714 hasBestOaLocation W20236047141 @default.
- W2023604714 hasConcept C104292427 @default.
- W2023604714 hasConcept C104317684 @default.
- W2023604714 hasConcept C108625454 @default.
- W2023604714 hasConcept C12554922 @default.
- W2023604714 hasConcept C140704245 @default.
- W2023604714 hasConcept C153911025 @default.
- W2023604714 hasConcept C159047783 @default.
- W2023604714 hasConcept C159654299 @default.
- W2023604714 hasConcept C178790620 @default.
- W2023604714 hasConcept C185592680 @default.
- W2023604714 hasConcept C195616568 @default.
- W2023604714 hasConcept C2522874641 @default.
- W2023604714 hasConcept C2776258796 @default.
- W2023604714 hasConcept C2776403692 @default.
- W2023604714 hasConcept C2777995582 @default.
- W2023604714 hasConcept C2779546866 @default.
- W2023604714 hasConcept C2779909307 @default.