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- W2023606072 abstract "Abstract Farnesylation of Ras (p21) protein by farnesyl-protein transferase (FPTase) is essential for cell-transforming activity in several tumor-types. Inhibition of FPTase activity has been shown to inhibit ras- dependent cell transformation and tumor size in nude mice thereby validating FPTase as a potential target for anticancer drugs. Our continued search for such inhibitors led to the isolation of cylindrol A, a bicyclic resorcinaldehyde cyclohexanone propionate derivative, from Cylidrocarpon lucidum. The isolation, structure elucidation by NMR and X-ray crystallographic methods, stereochemistry and FPTase activity of cylindrol A are described." @default.
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- W2023606072 date "1995-07-01" @default.
- W2023606072 modified "2023-10-11" @default.
- W2023606072 title "Cylindrol A: A novel inhibitor of Ras farnesyl-protein transferase from Cylindrocarpon lucidum" @default.
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- W2023606072 doi "https://doi.org/10.1016/0040-4039(95)00896-k" @default.
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