Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023606476> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2023606476 abstract "The antihistamine methapyrilene hydrochloride (MP) has been shown to be a potent hepatocarcinogen in rats, but not in hamsters or guinea pigs. This finding is in contrast to the relative nongenotoxicity of this compound. MP has been evaluated for genotoxicity in a wide variety of short-term tests and has generally demonstrated little genotoxic activity. One exception to this is the mouse lymphoma L5178Y mutagenesis assay, in which MP produced a very significant increase in small colony mutants with concomitant chromosomal damage in these cells. MP also induced positive responses in several cell transformation assays. One potentially very significant effect of MP is that it induces a large increase in hepatic cell proliferation coupled with mitochondrial proliferation in the livers of treated animals. This effect is discussed as a possible mechanism of liver tumor induction in rats." @default.
- W2023606476 created "2016-06-24" @default.
- W2023606476 creator A5062741465 @default.
- W2023606476 date "1987-05-01" @default.
- W2023606476 modified "2023-09-23" @default.
- W2023606476 title "Genotoxicity, toxicity, and carcinogenicity of the antihistamine methapyrilene (MTR 07216)" @default.
- W2023606476 cites W1866135219 @default.
- W2023606476 cites W1876317263 @default.
- W2023606476 cites W1966259585 @default.
- W2023606476 cites W1966864081 @default.
- W2023606476 cites W1975587742 @default.
- W2023606476 cites W1979350815 @default.
- W2023606476 cites W1993791842 @default.
- W2023606476 cites W1994533112 @default.
- W2023606476 cites W2000766002 @default.
- W2023606476 cites W2003136438 @default.
- W2023606476 cites W2026221924 @default.
- W2023606476 cites W2036242336 @default.
- W2023606476 cites W2042359280 @default.
- W2023606476 cites W2053687287 @default.
- W2023606476 cites W2058495576 @default.
- W2023606476 cites W2058612744 @default.
- W2023606476 cites W2062774884 @default.
- W2023606476 cites W2069866944 @default.
- W2023606476 cites W2070084657 @default.
- W2023606476 cites W2075737881 @default.
- W2023606476 cites W2092394340 @default.
- W2023606476 cites W2107398593 @default.
- W2023606476 cites W2137223879 @default.
- W2023606476 cites W2170069625 @default.
- W2023606476 cites W2309075492 @default.
- W2023606476 doi "https://doi.org/10.1016/0165-1110(87)90022-4" @default.
- W2023606476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3553919" @default.
- W2023606476 hasPublicationYear "1987" @default.
- W2023606476 type Work @default.
- W2023606476 sameAs 2023606476 @default.
- W2023606476 citedByCount "42" @default.
- W2023606476 countsByYear W20236064762012 @default.
- W2023606476 countsByYear W20236064762013 @default.
- W2023606476 countsByYear W20236064762015 @default.
- W2023606476 countsByYear W20236064762018 @default.
- W2023606476 crossrefType "journal-article" @default.
- W2023606476 hasAuthorship W2023606476A5062741465 @default.
- W2023606476 hasConcept C104317684 @default.
- W2023606476 hasConcept C114246631 @default.
- W2023606476 hasConcept C143065580 @default.
- W2023606476 hasConcept C153911025 @default.
- W2023606476 hasConcept C16318435 @default.
- W2023606476 hasConcept C178790620 @default.
- W2023606476 hasConcept C185592680 @default.
- W2023606476 hasConcept C2776880894 @default.
- W2023606476 hasConcept C2778959862 @default.
- W2023606476 hasConcept C29730261 @default.
- W2023606476 hasConcept C55493867 @default.
- W2023606476 hasConcept C555283112 @default.
- W2023606476 hasConcept C86803240 @default.
- W2023606476 hasConcept C98274493 @default.
- W2023606476 hasConceptScore W2023606476C104317684 @default.
- W2023606476 hasConceptScore W2023606476C114246631 @default.
- W2023606476 hasConceptScore W2023606476C143065580 @default.
- W2023606476 hasConceptScore W2023606476C153911025 @default.
- W2023606476 hasConceptScore W2023606476C16318435 @default.
- W2023606476 hasConceptScore W2023606476C178790620 @default.
- W2023606476 hasConceptScore W2023606476C185592680 @default.
- W2023606476 hasConceptScore W2023606476C2776880894 @default.
- W2023606476 hasConceptScore W2023606476C2778959862 @default.
- W2023606476 hasConceptScore W2023606476C29730261 @default.
- W2023606476 hasConceptScore W2023606476C55493867 @default.
- W2023606476 hasConceptScore W2023606476C555283112 @default.
- W2023606476 hasConceptScore W2023606476C86803240 @default.
- W2023606476 hasConceptScore W2023606476C98274493 @default.
- W2023606476 hasLocation W20236064761 @default.
- W2023606476 hasLocation W20236064762 @default.
- W2023606476 hasOpenAccess W2023606476 @default.
- W2023606476 hasPrimaryLocation W20236064761 @default.
- W2023606476 hasRelatedWork W1594770127 @default.
- W2023606476 hasRelatedWork W172564145 @default.
- W2023606476 hasRelatedWork W1810791988 @default.
- W2023606476 hasRelatedWork W185636444 @default.
- W2023606476 hasRelatedWork W2064977254 @default.
- W2023606476 hasRelatedWork W2141633893 @default.
- W2023606476 hasRelatedWork W2470490897 @default.
- W2023606476 hasRelatedWork W2585412962 @default.
- W2023606476 hasRelatedWork W2610792185 @default.
- W2023606476 hasRelatedWork W3207677898 @default.
- W2023606476 isParatext "false" @default.
- W2023606476 isRetracted "false" @default.
- W2023606476 magId "2023606476" @default.
- W2023606476 workType "article" @default.