FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023606914> ?p ?o ?g. }

• W2023606914 endingPage "e5352" @default.
• W2023606914 startingPage "e5352" @default.
• W2023606914 abstract "West Nile virus (WNV) has emerged globally as an increasingly important pathogen for humans and domestic animals. Studies of the evolutionary diversity of the virus over its known history will help to elucidate conserved sites, and characterize their correspondence to other pathogens and their relevance to the immune system. We describe a large-scale analysis of the entire WNV proteome, aimed at identifying and characterizing evolutionarily conserved amino acid sequences. This study, which used 2,746 WNV protein sequences collected from the NCBI GenPept database, focused on analysis of peptides of length 9 amino acids or more, which are immunologically relevant as potential T-cell epitopes. Entropy-based analysis of the diversity of WNV sequences, revealed the presence of numerous evolutionarily stable nonamer positions across the proteome (entropy value of < or = 1). The representation (frequency) of nonamers variant to the predominant peptide at these stable positions was, generally, low (< or = 10% of the WNV sequences analyzed). Eighty-eight fragments of length 9-29 amino acids, representing approximately 34% of the WNV polyprotein length, were identified to be identical and evolutionarily stable in all analyzed WNV sequences. Of the 88 completely conserved sequences, 67 are also present in other flaviviruses, and several have been associated with the functional and structural properties of viral proteins. Immunoinformatic analysis revealed that the majority (78/88) of conserved sequences are potentially immunogenic, while 44 contained experimentally confirmed human T-cell epitopes. This study identified a comprehensive catalogue of completely conserved WNV sequences, many of which are shared by other flaviviruses, and majority are potential epitopes. The complete conservation of these immunologically relevant sequences through the entire recorded WNV history suggests they will be valuable as components of peptide-specific vaccines or other therapeutic applications, for sequence-specific diagnosis of a wide-range of Flavivirus infections, and for studies of homologous sequences among other flaviviruses." @default.
• W2023606914 created "2016-06-24" @default.
• W2023606914 creator A5000965422 @default.
• W2023606914 creator A5006408722 @default.
• W2023606914 creator A5008594188 @default.
• W2023606914 creator A5013902423 @default.
• W2023606914 creator A5033320228 @default.
• W2023606914 creator A5037664479 @default.
• W2023606914 creator A5052502655 @default.
• W2023606914 creator A5067724472 @default.
• W2023606914 creator A5089063979 @default.
• W2023606914 date "2009-04-29" @default.
• W2023606914 modified "2023-09-23" @default.
• W2023606914 title "Conservation and Variability of West Nile Virus Proteins" @default.
• W2023606914 cites W1572786643 @default.
• W2023606914 cites W1582754056 @default.
• W2023606914 cites W1893064134 @default.
• W2023606914 cites W1963891393 @default.
• W2023606914 cites W1965582988 @default.
• W2023606914 cites W1966499706 @default.
• W2023606914 cites W1982481323 @default.
• W2023606914 cites W1983360668 @default.
• W2023606914 cites W1985993304 @default.
• W2023606914 cites W1991461541 @default.
• W2023606914 cites W1995875735 @default.
• W2023606914 cites W2001707651 @default.
• W2023606914 cites W2004996851 @default.
• W2023606914 cites W2005262608 @default.
• W2023606914 cites W2024543747 @default.
• W2023606914 cites W2028064829 @default.
• W2023606914 cites W2036353957 @default.
• W2023606914 cites W2042279032 @default.
• W2023606914 cites W2042777577 @default.
• W2023606914 cites W2060333218 @default.
• W2023606914 cites W2061557516 @default.
• W2023606914 cites W2068945309 @default.
• W2023606914 cites W2076639605 @default.
• W2023606914 cites W2080405903 @default.
• W2023606914 cites W2087606023 @default.
• W2023606914 cites W2095767844 @default.
• W2023606914 cites W2103148772 @default.
• W2023606914 cites W2104568825 @default.
• W2023606914 cites W2106882534 @default.
• W2023606914 cites W2110828961 @default.
• W2023606914 cites W2124028633 @default.
• W2023606914 cites W2125079066 @default.
• W2023606914 cites W2130479394 @default.
• W2023606914 cites W2132926880 @default.
• W2023606914 cites W2134220504 @default.
• W2023606914 cites W2137159492 @default.
• W2023606914 cites W2137558232 @default.
• W2023606914 cites W2138306892 @default.
• W2023606914 cites W2140630012 @default.
• W2023606914 cites W2142831360 @default.
• W2023606914 cites W2151624287 @default.
• W2023606914 cites W2152178770 @default.
• W2023606914 cites W2154666681 @default.
• W2023606914 cites W2163928116 @default.
• W2023606914 cites W4210400672 @default.
• W2023606914 cites W4233093275 @default.
• W2023606914 cites W4241530011 @default.
• W2023606914 cites W4245803912 @default.
• W2023606914 cites W4246769581 @default.
• W2023606914 cites W4255923789 @default.
• W2023606914 doi "https://doi.org/10.1371/journal.pone.0005352" @default.
• W2023606914 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2670515" @default.
• W2023606914 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19401763" @default.
• W2023606914 hasPublicationYear "2009" @default.
• W2023606914 type Work @default.
• W2023606914 sameAs 2023606914 @default.
• W2023606914 citedByCount "24" @default.
• W2023606914 countsByYear W20236069142012 @default.
• W2023606914 countsByYear W20236069142013 @default.
• W2023606914 countsByYear W20236069142014 @default.
• W2023606914 countsByYear W20236069142017 @default.
• W2023606914 countsByYear W20236069142018 @default.
• W2023606914 countsByYear W20236069142019 @default.
• W2023606914 countsByYear W20236069142020 @default.
• W2023606914 countsByYear W20236069142021 @default.
• W2023606914 countsByYear W20236069142022 @default.
• W2023606914 crossrefType "journal-article" @default.
• W2023606914 hasAuthorship W2023606914A5000965422 @default.
• W2023606914 hasAuthorship W2023606914A5006408722 @default.
• W2023606914 hasAuthorship W2023606914A5008594188 @default.
• W2023606914 hasAuthorship W2023606914A5013902423 @default.
• W2023606914 hasAuthorship W2023606914A5033320228 @default.
• W2023606914 hasAuthorship W2023606914A5037664479 @default.
• W2023606914 hasAuthorship W2023606914A5052502655 @default.
• W2023606914 hasAuthorship W2023606914A5067724472 @default.
• W2023606914 hasAuthorship W2023606914A5089063979 @default.
• W2023606914 hasBestOaLocation W20236069141 @default.
• W2023606914 hasConcept C104317684 @default.
• W2023606914 hasConcept C104397665 @default.
• W2023606914 hasConcept C159047783 @default.
• W2023606914 hasConcept C159654299 @default.
• W2023606914 hasConcept C167625842 @default.
• W2023606914 hasConcept C193252679 @default.
• W2023606914 hasConcept C195616568 @default.

• next