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- W2023606937 abstract "We developed a system for time-lapse observation of identified neurons in the central nervous system (CNS) of the Drosophila embryo. Using this system, we characterize the dynamics of filopodia and axon growth of the motorneuron RP2 as it navigates anteriorly through the CNS and then laterally along the intersegmental nerve (ISN) into the periphery. We find that both axonal extension and turning occur primarily through the process of filopodial dilation. In addition, we used the GAL4-UAS system to express the fusion protein Tau-GFP in a subset of neurons, allowing us to correlate RP2's patterns of growth with a subset of axons in its environment. In particular, we show that RP2's sharp lateral turn is coincident with the nascent ISN. © 1998 John Wiley & Sons, Inc. J Neurobiol 37: 607–621, 1998" @default.
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- W2023606937 date "1998-12-01" @default.
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- W2023606937 title "In vivo dynamics of axon pathfinding in theDrosophila CNS: A time-lapse study of an identified motorneuron" @default.
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- W2023606937 doi "https://doi.org/10.1002/(sici)1097-4695(199812)37:4<607::aid-neu9>3.0.co;2-q" @default.
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