Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023607235> ?p ?o ?g. }
- W2023607235 endingPage "4907" @default.
- W2023607235 startingPage "4897" @default.
- W2023607235 abstract "ABSTRACT Antivector immunity limits the response to homologous boosting for viral vector vaccines. Here, we describe a new, potent vaccine vector based on replication-competent vesicular stomatitis virus pseudotyped with the glycoprotein of the lymphocytic choriomeningitis virus (VSV-GP), which we previously showed to be safe in mice. In mice, VSV and VSV-GP encoding ovalbumin (OVA) as a model antigen (VSV-OVA and VSV-GP-OVA) induced equal levels of OVA-specific humoral and cellular immune responses upon a single immunization. However, boosting with the same vector was possible only for VSV-GP-OVA as neutralizing antibodies to VSV limited the immunogenicity of the VSV-OVA boost. OVA-specific cytotoxic T-lymphocyte (CTL) responses induced by VSV-GP-OVA were at least as potent as those induced by an adenoviral state-of-the-art vaccine vector and completely protected mice in a Listeria monocytogenes challenge model. VSV-GP is so far the only replication-competent vaccine vector that does not lose efficacy upon repeated application. IMPORTANCE Although there has been great progress in treatment and prevention of infectious diseases in the past several years, effective vaccines against some of the most serious infections, e.g., AIDS, malaria, hepatitis C, or tuberculosis, are urgently needed. Here, several approaches based on viral vector vaccines are under development. However, for all viral vaccine vectors currently in clinical testing, repeated application is limited by neutralizing antibodies to the vector itself. Here, we have exploited the potential of vesicular stomatitis virus pseudotyped with the glycoprotein of the lymphocytic choriomeningitis virus (VSV-GP) as a vaccine platform. VSV-GP is the first replication-competent viral vector vaccine that does not induce vector-specific humoral immunity, i.e., neutralizing antibodies, and therefore can boost immune responses against a foreign antigen by repeated applications. The vector allows introduction of various antigens and therefore can serve as a platform technology for the development of novel vaccines against a broad spectrum of diseases." @default.
- W2023607235 created "2016-06-24" @default.
- W2023607235 creator A5008537578 @default.
- W2023607235 creator A5017068102 @default.
- W2023607235 creator A5031826508 @default.
- W2023607235 creator A5034636892 @default.
- W2023607235 creator A5040057969 @default.
- W2023607235 creator A5047271069 @default.
- W2023607235 creator A5052971511 @default.
- W2023607235 creator A5063055218 @default.
- W2023607235 creator A5072146936 @default.
- W2023607235 creator A5077529566 @default.
- W2023607235 date "2014-05-01" @default.
- W2023607235 modified "2023-10-18" @default.
- W2023607235 title "VSV-GP: a Potent Viral Vaccine Vector That Boosts the Immune Response upon Repeated Applications" @default.
- W2023607235 cites W1549271450 @default.
- W2023607235 cites W1924636867 @default.
- W2023607235 cites W1931750338 @default.
- W2023607235 cites W1965751112 @default.
- W2023607235 cites W1982805293 @default.
- W2023607235 cites W1984313604 @default.
- W2023607235 cites W1989069389 @default.
- W2023607235 cites W1991252832 @default.
- W2023607235 cites W1993037488 @default.
- W2023607235 cites W1999004290 @default.
- W2023607235 cites W2000529190 @default.
- W2023607235 cites W2003335806 @default.
- W2023607235 cites W2005654436 @default.
- W2023607235 cites W2018219929 @default.
- W2023607235 cites W2029325618 @default.
- W2023607235 cites W2036927742 @default.
- W2023607235 cites W2053032921 @default.
- W2023607235 cites W2054258731 @default.
- W2023607235 cites W2056416333 @default.
- W2023607235 cites W2060363530 @default.
- W2023607235 cites W2066144268 @default.
- W2023607235 cites W2068053683 @default.
- W2023607235 cites W2086172653 @default.
- W2023607235 cites W2089697291 @default.
- W2023607235 cites W2090738896 @default.
- W2023607235 cites W2091096335 @default.
- W2023607235 cites W2098213772 @default.
- W2023607235 cites W2107164056 @default.
- W2023607235 cites W2108807439 @default.
- W2023607235 cites W2111875244 @default.
- W2023607235 cites W2112383089 @default.
- W2023607235 cites W2113983720 @default.
- W2023607235 cites W2114608008 @default.
- W2023607235 cites W2114941904 @default.
- W2023607235 cites W2124603089 @default.
- W2023607235 cites W2131664226 @default.
- W2023607235 cites W2137835553 @default.
- W2023607235 cites W2140997748 @default.
- W2023607235 cites W2142829045 @default.
- W2023607235 cites W2146967773 @default.
- W2023607235 cites W2146986766 @default.
- W2023607235 cites W2148029978 @default.
- W2023607235 cites W2149294465 @default.
- W2023607235 cites W2149472519 @default.
- W2023607235 cites W2150906132 @default.
- W2023607235 cites W2153028137 @default.
- W2023607235 cites W2153670011 @default.
- W2023607235 cites W2157434814 @default.
- W2023607235 cites W2158734363 @default.
- W2023607235 cites W2160942323 @default.
- W2023607235 cites W2162891851 @default.
- W2023607235 cites W2176798835 @default.
- W2023607235 cites W2414650372 @default.
- W2023607235 cites W84968995 @default.
- W2023607235 doi "https://doi.org/10.1128/jvi.03276-13" @default.
- W2023607235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3993835" @default.
- W2023607235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24554655" @default.
- W2023607235 hasPublicationYear "2014" @default.
- W2023607235 type Work @default.
- W2023607235 sameAs 2023607235 @default.
- W2023607235 citedByCount "46" @default.
- W2023607235 countsByYear W20236072352014 @default.
- W2023607235 countsByYear W20236072352016 @default.
- W2023607235 countsByYear W20236072352017 @default.
- W2023607235 countsByYear W20236072352018 @default.
- W2023607235 countsByYear W20236072352019 @default.
- W2023607235 countsByYear W20236072352020 @default.
- W2023607235 countsByYear W20236072352021 @default.
- W2023607235 countsByYear W20236072352022 @default.
- W2023607235 countsByYear W20236072352023 @default.
- W2023607235 crossrefType "journal-article" @default.
- W2023607235 hasAuthorship W2023607235A5008537578 @default.
- W2023607235 hasAuthorship W2023607235A5017068102 @default.
- W2023607235 hasAuthorship W2023607235A5031826508 @default.
- W2023607235 hasAuthorship W2023607235A5034636892 @default.
- W2023607235 hasAuthorship W2023607235A5040057969 @default.
- W2023607235 hasAuthorship W2023607235A5047271069 @default.
- W2023607235 hasAuthorship W2023607235A5052971511 @default.
- W2023607235 hasAuthorship W2023607235A5063055218 @default.
- W2023607235 hasAuthorship W2023607235A5072146936 @default.
- W2023607235 hasAuthorship W2023607235A5077529566 @default.
- W2023607235 hasBestOaLocation W20236072351 @default.
- W2023607235 hasConcept C104317684 @default.