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• W2023607416 abstract "The pharmacokinetic interaction between sildenafil, a phosphodiesterase type 5 (PDE-5) inhibitor, and ambrisentan, an ETA-selective, propanoic acid—based endothelin receptor antagonist (ERA), was studied in a 2-period crossover study in 19 healthy volunteers, with ambrisentan exposure (AUC0-∞) and maximum plasma concentration (Cmax) determined over 24 hours for a 10-mg dose of ambrisentan alone and again after 7 days of sildenafil 20 mg 3 times daily. The AUC0-∞ and Cmax for sildenafil and N-desmethyl sildenafil (active metabolite) were determined over 24 hours for a 20-mg dose of sildenafil alone and again after 7 days of dosing with ambrisentan 10 mg once daily. There was no clinically relevant pharmacokinetic interaction between ambrisentan and sildenafil or N-desmethyl sildenafil. Ambrisentan Cmax was unchanged (96.3% [90% confidence interval: 86.0%-107.8%]), with a minor increase in AUC0-∞(108.5% [102.6%-111.7%]) with sildenafil coadministration. Sildenafil Cmax was increased slightly (113.4% [99.6%-129.1%]), and AUC0-∞ was unchanged (98.7% [91.2%-110.5%]) with ambrisentan coadministration. N-desmethyl sildenafil was unaltered. Dose adjustment of either drug is not necessary compared with administration alone." @default.
• W2023607416 created "2016-06-24" @default.
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• W2023607416 date "2008-12-01" @default.
• W2023607416 modified "2023-10-04" @default.
• W2023607416 title "Pharmacokinetics and Safety of Ambrisentan in Combination With Sildenafil in Healthy Volunteers" @default.
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• W2023607416 doi "https://doi.org/10.1177/0091270008324180" @default.
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