FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023607520> ?p ?o ?g. }

• W2023607520 endingPage "267" @default.
• W2023607520 startingPage "251" @default.
• W2023607520 abstract "Brain-derived neurotrophic factor (BDNF) signalling is critical for neuronal development and transmission. Recruitment of TrkB receptors to lipid rafts has been shown to be necessary for the activation of specific signalling pathways and modulation of neurotransmitter release by BDNF. Since TrkB receptors are known to be modulated by adenosine A(2A) receptor activation, we hypothesized that activation of A(2A) receptors could influence TrkB receptor localization among different membrane microdomains. We found that adenosine A(2A) receptor agonists increased the levels of TrkB receptors in the lipid raft fraction of cortical membranes and potentiated BDNF-induced augmentation of phosphorylated TrkB levels in lipid rafts. Blockade of the clathrin-mediated endocytosis with monodansyl cadaverine (100 μM) did not modify the effects of the A(2A) receptor agonists, but significantly impaired BDNF effects on TrkB recruitment to lipid rafts. The effect of A(2A) receptor activation in TrkB localization was mimicked by 5 μM forskolin, an adenylyl cyclase activator. Also, it was blocked by the PKA inhibitors RpcAMPs and PKI-(14-22) and by the Src-family kinase inhibitor PP2. Moreover, removal of endogenous adenosine or disruption of lipid rafts reduced BDNF stimulatory effects on glutamate release from cortical synaptosomes. Lipid raft integrity was also required for the effects of BDNF upon hippocampal long-term potentiation at CA1 synapses. Our data demonstrate, for the first time, a BDNF-independent recruitment of TrkB receptors to lipid rafts, induced by the activation of adenosine A(2A) receptors, with functional consequences for TrkB phosphorylation and BDNF-induced modulation of neurotransmitter release and hippocampal plasticity." @default.
• W2023607520 created "2016-06-24" @default.
• W2023607520 creator A5021255614 @default.
• W2023607520 creator A5031100369 @default.
• W2023607520 creator A5031806410 @default.
• W2023607520 creator A5045671057 @default.
• W2023607520 creator A5087876357 @default.
• W2023607520 date "2013-08-20" @default.
• W2023607520 modified "2023-10-13" @default.
• W2023607520 title "Regulation of TrkB receptor translocation to lipid rafts by adenosine A2A receptors and its functional implications for BDNF-induced regulation of synaptic plasticity" @default.
• W2023607520 cites W1319875 @default.
• W2023607520 cites W1530428799 @default.
• W2023607520 cites W1553513611 @default.
• W2023607520 cites W1564861448 @default.
• W2023607520 cites W1600856176 @default.
• W2023607520 cites W1611901737 @default.
• W2023607520 cites W1965993201 @default.
• W2023607520 cites W1971263143 @default.
• W2023607520 cites W1976138207 @default.
• W2023607520 cites W1980218345 @default.
• W2023607520 cites W1989034907 @default.
• W2023607520 cites W1990320001 @default.
• W2023607520 cites W1990479642 @default.
• W2023607520 cites W1991323513 @default.
• W2023607520 cites W1993357003 @default.
• W2023607520 cites W2010121960 @default.
• W2023607520 cites W2011588737 @default.
• W2023607520 cites W2012423618 @default.
• W2023607520 cites W2014270209 @default.
• W2023607520 cites W2014283755 @default.
• W2023607520 cites W2023653650 @default.
• W2023607520 cites W2031107029 @default.
• W2023607520 cites W2037721754 @default.
• W2023607520 cites W2044350453 @default.
• W2023607520 cites W2054628503 @default.
• W2023607520 cites W2055085733 @default.
• W2023607520 cites W2060411448 @default.
• W2023607520 cites W2060832818 @default.
• W2023607520 cites W2065098417 @default.
• W2023607520 cites W2069488037 @default.
• W2023607520 cites W2072500349 @default.
• W2023607520 cites W2074166779 @default.
• W2023607520 cites W2074827827 @default.
• W2023607520 cites W2077535383 @default.
• W2023607520 cites W2077720722 @default.
• W2023607520 cites W2081486880 @default.
• W2023607520 cites W2087036140 @default.
• W2023607520 cites W2089643815 @default.
• W2023607520 cites W2090872774 @default.
• W2023607520 cites W2094544368 @default.
• W2023607520 cites W2097783529 @default.
• W2023607520 cites W2102929715 @default.
• W2023607520 cites W2111070504 @default.
• W2023607520 cites W2116999551 @default.
• W2023607520 cites W2130388575 @default.
• W2023607520 cites W2132369117 @default.
• W2023607520 cites W2137667039 @default.
• W2023607520 cites W2139817708 @default.
• W2023607520 cites W2139846514 @default.
• W2023607520 cites W2142325305 @default.
• W2023607520 cites W2145748438 @default.
• W2023607520 cites W2155056221 @default.
• W2023607520 cites W2157714782 @default.
• W2023607520 cites W4293247451 @default.
• W2023607520 cites W84361437 @default.
• W2023607520 doi "https://doi.org/10.1007/s11302-013-9383-2" @default.
• W2023607520 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4040169" @default.
• W2023607520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24271058" @default.
• W2023607520 hasPublicationYear "2013" @default.
• W2023607520 type Work @default.
• W2023607520 sameAs 2023607520 @default.
• W2023607520 citedByCount "33" @default.
• W2023607520 countsByYear W20236075202013 @default.
• W2023607520 countsByYear W20236075202014 @default.
• W2023607520 countsByYear W20236075202015 @default.
• W2023607520 countsByYear W20236075202016 @default.
• W2023607520 countsByYear W20236075202017 @default.
• W2023607520 countsByYear W20236075202018 @default.
• W2023607520 countsByYear W20236075202019 @default.
• W2023607520 countsByYear W20236075202020 @default.
• W2023607520 countsByYear W20236075202021 @default.
• W2023607520 countsByYear W20236075202022 @default.
• W2023607520 countsByYear W20236075202023 @default.
• W2023607520 crossrefType "journal-article" @default.
• W2023607520 hasAuthorship W2023607520A5021255614 @default.
• W2023607520 hasAuthorship W2023607520A5031100369 @default.
• W2023607520 hasAuthorship W2023607520A5031806410 @default.
• W2023607520 hasAuthorship W2023607520A5045671057 @default.
• W2023607520 hasAuthorship W2023607520A5087876357 @default.
• W2023607520 hasBestOaLocation W20236075202 @default.
• W2023607520 hasConcept C126322002 @default.
• W2023607520 hasConcept C134018914 @default.
• W2023607520 hasConcept C134139212 @default.
• W2023607520 hasConcept C160539049 @default.
• W2023607520 hasConcept C170493617 @default.
• W2023607520 hasConcept C172590197 @default.
• W2023607520 hasConcept C185592680 @default.
• W2023607520 hasConcept C2778790584 @default.

• next