FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023608437> ?p ?o ?g. }

• W2023608437 endingPage "120179" @default.
• W2023608437 startingPage "120179" @default.
• W2023608437 abstract "Progression through the eukaryotic cell cycle is characterized by specific transitions, where cells move irreversibly from stage i −1 of the cycle into stage i . These irreversible cell cycle transitions are regulated by underlying bistable switches, which share some common features. An inhibitory protein stalls progression, and an activatory protein promotes progression. The inhibitor and activator are locked in a double-negative feedback loop, creating a one-way toggle switch that guarantees an irreversible commitment to move forward through the cell cycle, and it opposes regression from stage i to stage i −1. In many cases, the activator is an enzyme that modifies the inhibitor in multiple steps, whereas the hypo-modified inhibitor binds strongly to the activator and resists its enzymatic activity. These interactions are the basis of a reaction motif that provides a simple and generic account of many characteristic properties of cell cycle transitions. To demonstrate this assertion, we apply the motif in detail to the G1/S transition in budding yeast and to the mitotic checkpoint in mammalian cells. Variations of the motif might support irreversible cellular decision-making in other contexts." @default.
• W2023608437 created "2016-06-24" @default.
• W2023608437 creator A5017537896 @default.
• W2023608437 creator A5020843492 @default.
• W2023608437 creator A5028908910 @default.
• W2023608437 creator A5060336051 @default.
• W2023608437 date "2013-03-01" @default.
• W2023608437 modified "2023-09-25" @default.
• W2023608437 title "Molecular mechanisms creating bistable switches at cell cycle transitions" @default.
• W2023608437 cites W113252703 @default.
• W2023608437 cites W1483395792 @default.
• W2023608437 cites W1512545619 @default.
• W2023608437 cites W1778446120 @default.
• W2023608437 cites W1969236463 @default.
• W2023608437 cites W1970740484 @default.
• W2023608437 cites W1975507400 @default.
• W2023608437 cites W1976067971 @default.
• W2023608437 cites W1978850887 @default.
• W2023608437 cites W1980487829 @default.
• W2023608437 cites W1985482863 @default.
• W2023608437 cites W1989290713 @default.
• W2023608437 cites W1989830594 @default.
• W2023608437 cites W1994500037 @default.
• W2023608437 cites W1998399279 @default.
• W2023608437 cites W2000619385 @default.
• W2023608437 cites W2015038174 @default.
• W2023608437 cites W2021278812 @default.
• W2023608437 cites W2029158215 @default.
• W2023608437 cites W2031332408 @default.
• W2023608437 cites W2032629746 @default.
• W2023608437 cites W2037992356 @default.
• W2023608437 cites W2043190827 @default.
• W2023608437 cites W2044312503 @default.
• W2023608437 cites W2047746661 @default.
• W2023608437 cites W2048938594 @default.
• W2023608437 cites W2059345773 @default.
• W2023608437 cites W2065629914 @default.
• W2023608437 cites W2074126694 @default.
• W2023608437 cites W2075408326 @default.
• W2023608437 cites W2076650991 @default.
• W2023608437 cites W2077326330 @default.
• W2023608437 cites W2078477504 @default.
• W2023608437 cites W2083474696 @default.
• W2023608437 cites W2099558654 @default.
• W2023608437 cites W2114638000 @default.
• W2023608437 cites W2126683450 @default.
• W2023608437 cites W2128626625 @default.
• W2023608437 cites W2133401281 @default.
• W2023608437 cites W2135535700 @default.
• W2023608437 cites W2137932686 @default.
• W2023608437 cites W2150767223 @default.
• W2023608437 cites W2153100796 @default.
• W2023608437 cites W2154625195 @default.
• W2023608437 cites W2163279255 @default.
• W2023608437 cites W2167395885 @default.
• W2023608437 cites W2361838659 @default.
• W2023608437 cites W4230713695 @default.
• W2023608437 doi "https://doi.org/10.1098/rsob.120179" @default.
• W2023608437 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3718337" @default.
• W2023608437 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23486222" @default.
• W2023608437 hasPublicationYear "2013" @default.
• W2023608437 type Work @default.
• W2023608437 sameAs 2023608437 @default.
• W2023608437 citedByCount "63" @default.
• W2023608437 countsByYear W20236084372013 @default.
• W2023608437 countsByYear W20236084372014 @default.
• W2023608437 countsByYear W20236084372015 @default.
• W2023608437 countsByYear W20236084372016 @default.
• W2023608437 countsByYear W20236084372017 @default.
• W2023608437 countsByYear W20236084372018 @default.
• W2023608437 countsByYear W20236084372019 @default.
• W2023608437 countsByYear W20236084372020 @default.
• W2023608437 countsByYear W20236084372021 @default.
• W2023608437 countsByYear W20236084372022 @default.
• W2023608437 crossrefType "journal-article" @default.
• W2023608437 hasAuthorship W2023608437A5017537896 @default.
• W2023608437 hasAuthorship W2023608437A5020843492 @default.
• W2023608437 hasAuthorship W2023608437A5028908910 @default.
• W2023608437 hasAuthorship W2023608437A5060336051 @default.
• W2023608437 hasBestOaLocation W20236084371 @default.
• W2023608437 hasConcept C104317684 @default.
• W2023608437 hasConcept C119599485 @default.
• W2023608437 hasConcept C121332964 @default.
• W2023608437 hasConcept C127413603 @default.
• W2023608437 hasConcept C1491633281 @default.
• W2023608437 hasConcept C29537977 @default.
• W2023608437 hasConcept C2994037739 @default.
• W2023608437 hasConcept C48207687 @default.
• W2023608437 hasConcept C54355233 @default.
• W2023608437 hasConcept C62520636 @default.
• W2023608437 hasConcept C86803240 @default.
• W2023608437 hasConcept C88045685 @default.
• W2023608437 hasConcept C93304396 @default.
• W2023608437 hasConcept C95444343 @default.
• W2023608437 hasConcept C97292510 @default.
• W2023608437 hasConceptScore W2023608437C104317684 @default.
• W2023608437 hasConceptScore W2023608437C119599485 @default.
• W2023608437 hasConceptScore W2023608437C121332964 @default.

• next