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- W2023609566 abstract "We performed a genetic analysis of 331 nonsyndromic cleft lip with or without cleft palate (CL ± P) proband families ascertained in Madras, India. Predictions of the multifactorial threshold (MF/T) model are tested; goodness-of-fit tests of the MF/T model and complex segregation analysis are also utilized to clarify the genetic etiology of CL ± P in this study population. There was little evidence for the MF/T model. The most reasonable conclusion from mixed model analysis is that of a major locus with reduced transmission probability. This is not altogether surprising if manifestation of CL ± P also depends on in utero exposure to harmful environmental agents during the critical period of facial development, as suggested by Melnick et al. [1980] and demonstrated in an animal model of CL ± P [Melnick et al., 1981]. Further the results in the Madras population are quite similar to those in other populations of Europe and Asia." @default.
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- W2023609566 title "Genetic analysis of cleft lip with or without cleft palate in Madras, India" @default.
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- W2023609566 doi "https://doi.org/10.1002/ajmg.1320420103" @default.
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