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- W2023609941 abstract "A non-steady-state model is discussed for the study of the interplay between β-lactamase activity and outer membrane permeability with slowly hydrolysed β-lactams. The analysis shows: (1) that the simple, steady-state model presented in the accompanying paper remains valid as long as kcat (i.e. k3 with chromosome-encoded class C β-lactamases) is larger than 10−3/sec (generation time = 20 min or more); (2) that among the β-lactam antibiotics studied here, the complete, non-steady-state model needs only be used in the case of aztreonam; (3) that the term “trapping” should be replaced by “formation of a covalent acyl-enzyme” and that such a phenomenon only contributes significantly to the resistance when penetration and hydrolysis are very slow and the periplasmic β-lactamase concentration is very high. Aztreonam seems to be the only compound which fulfils the first two conditions." @default.
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- W2023609941 date "1989-05-01" @default.
- W2023609941 modified "2023-09-29" @default.
- W2023609941 title "Quantitative relationship between sensitivity to β-lactam antibiotics and β-lactamase production in gram-negative bacteria—II" @default.
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- W2023609941 doi "https://doi.org/10.1016/0006-2952(89)90181-0" @default.
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