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• W2023618042 endingPage "2323" @default.
• W2023618042 startingPage "2320" @default.
• W2023618042 abstract "A series of 2-arylamino-5-aryl-1,3,4-thiadiazoles 1a–j were synthesized and screened for their anticancer activity against various human cancer cell lines. The novel one-pot synthesis of 1,3,4-thiadiazoles was achieved by refluxing aryl aldehydes, hydrazine hydrate, and aryl isothiocyanates in methanol followed by oxidative cyclization with ferric ammonium sulfate. The compounds 1g–j with trimethoxyphenyl at the C-5 position displayed extremely potent anticancer activity with at least twofold selectivity (IC50: 4.3–9.2 μM). The nature of substituent on the C-2 arylamino ring may be critical in opting for the selectivity towards a particular cancer cell." @default.
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• W2023618042 date "2011-04-01" @default.
• W2023618042 modified "2023-10-18" @default.
• W2023618042 title "One-pot synthesis and anticancer studies of 2-arylamino-5-aryl-1,3,4-thiadiazoles" @default.
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• W2023618042 doi "https://doi.org/10.1016/j.bmcl.2011.02.083" @default.
• W2023618042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21429743" @default.
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