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- W2023619212 abstract "Management of limited joint mobility in diabetic patients Michele Abate,1 Cosima Schiavone,1 Vincenzo Salini,1 Isabel Andia21Department of Medicine and Science of Aging, University G d'Annunzio, Chieti-Pescara, Italy; 2BioCruces Health Research Institute, Cruces University Hospital, Barakaldo, SpainAbstract: Several rheumatologic manifestations are more pronounced in subjects with diabetes, ie, frozen shoulder, rotator cuff tears, Dupuytren's contracture, trigger finger, cheiroarthropathy in the upper limb, and Achilles tendinopathy and plantar fasciitis in the lower limb. These conditions can limit the range of motion of the affected joint, thereby impairing function and ability to perform activities of daily living. This review provides a short description of diabetes-related joint diseases, the specific pathogenetic mechanisms involved, and the role of inflammation, overuse, and genetics, each of which activates a complex sequence of biochemical alterations. Diabetes is a causative factor in tendon diseases and amplifies the damage induced by other agents as well. According to an accepted hypothesis, damaged joint tissue in diabetes is caused by an excess of advanced glycation end products, which forms covalent cross-links within collagen fibers and alters their structure and function. Moreover, they interact with a variety of cell surface receptors, activating a number of effects, including pro-oxidant and proinflammatory events. Adiposity and advanced age, commonly associated with type 2 diabetes mellitus, are further pathogenetic factors. Prevention and strict control of this metabolic disorder is essential, because it has been demonstrated that limited joint motion is related to duration of the disease and hyperglycemia. Several treatments are used in clinical practice, but their mechanisms of action are not completely understood, and their efficacy is also debated.Keywords: diabetes mellitus, joint mobility, diabetic complication, tendon" @default.
- W2023619212 created "2016-06-24" @default.
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- W2023619212 date "2013-05-01" @default.
- W2023619212 modified "2023-09-28" @default.
- W2023619212 title "Management of limited joint mobility in diabetic patients" @default.
- W2023619212 cites W1490333102 @default.
- W2023619212 cites W1504387363 @default.
- W2023619212 cites W1560147020 @default.
- W2023619212 cites W1565094715 @default.
- W2023619212 cites W1571357218 @default.
- W2023619212 cites W1587146485 @default.
- W2023619212 cites W1592976983 @default.
- W2023619212 cites W171585542 @default.
- W2023619212 cites W1719451081 @default.
- W2023619212 cites W1892560055 @default.
- W2023619212 cites W1942752677 @default.
- W2023619212 cites W1966319901 @default.
- W2023619212 cites W1967173310 @default.
- W2023619212 cites W1972292971 @default.
- W2023619212 cites W1973193338 @default.
- W2023619212 cites W1975710635 @default.
- W2023619212 cites W1980559273 @default.
- W2023619212 cites W1981228003 @default.
- W2023619212 cites W1981742763 @default.
- W2023619212 cites W1982339374 @default.
- W2023619212 cites W1985848979 @default.
- W2023619212 cites W1986818994 @default.
- W2023619212 cites W1989376510 @default.
- W2023619212 cites W1990084533 @default.
- W2023619212 cites W1996573859 @default.
- W2023619212 cites W2002780273 @default.
- W2023619212 cites W2004403933 @default.
- W2023619212 cites W2007066698 @default.
- W2023619212 cites W2009338866 @default.
- W2023619212 cites W2013537969 @default.
- W2023619212 cites W2015695238 @default.
- W2023619212 cites W2019234500 @default.
- W2023619212 cites W2020955534 @default.
- W2023619212 cites W2021883643 @default.
- W2023619212 cites W2022356903 @default.
- W2023619212 cites W2027348958 @default.
- W2023619212 cites W2027914534 @default.
- W2023619212 cites W2028849212 @default.
- W2023619212 cites W2036199924 @default.
- W2023619212 cites W2036743645 @default.
- W2023619212 cites W2041106060 @default.
- W2023619212 cites W2041529707 @default.
- W2023619212 cites W2042707685 @default.
- W2023619212 cites W2043533802 @default.
- W2023619212 cites W2045351385 @default.
- W2023619212 cites W2046696056 @default.
- W2023619212 cites W2048091122 @default.
- W2023619212 cites W2051394898 @default.
- W2023619212 cites W2053685252 @default.
- W2023619212 cites W2053864537 @default.
- W2023619212 cites W2055065987 @default.
- W2023619212 cites W2059341662 @default.
- W2023619212 cites W2059951907 @default.
- W2023619212 cites W2061066196 @default.
- W2023619212 cites W2062147719 @default.
- W2023619212 cites W2066007233 @default.
- W2023619212 cites W2070291464 @default.
- W2023619212 cites W207076811 @default.
- W2023619212 cites W2070835870 @default.
- W2023619212 cites W2077891184 @default.
- W2023619212 cites W2080224893 @default.
- W2023619212 cites W2080563146 @default.
- W2023619212 cites W2082466238 @default.
- W2023619212 cites W2082487229 @default.
- W2023619212 cites W2082908125 @default.
- W2023619212 cites W2084751368 @default.
- W2023619212 cites W2086321305 @default.
- W2023619212 cites W2087001237 @default.
- W2023619212 cites W2089574035 @default.
- W2023619212 cites W2093374009 @default.
- W2023619212 cites W2093546798 @default.
- W2023619212 cites W2097392923 @default.
- W2023619212 cites W2098297523 @default.
- W2023619212 cites W2101001275 @default.
- W2023619212 cites W2103671501 @default.
- W2023619212 cites W2104514818 @default.
- W2023619212 cites W2106304188 @default.
- W2023619212 cites W2106752649 @default.
- W2023619212 cites W2108469967 @default.
- W2023619212 cites W2108762011 @default.
- W2023619212 cites W2113278103 @default.
- W2023619212 cites W2114472267 @default.
- W2023619212 cites W2114811832 @default.
- W2023619212 cites W2117291362 @default.
- W2023619212 cites W2119465826 @default.
- W2023619212 cites W2119614633 @default.
- W2023619212 cites W2129920090 @default.
- W2023619212 cites W2130363605 @default.
- W2023619212 cites W2131009584 @default.