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• W2023622908 endingPage "109" @default.
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• W2023622908 abstract "The present study evaluated the central effects of ß-funaltrexamine (B-FNA), a non-equilibrium antagonist of μ-opioid receptors and a reversible agonist of κ-opioid receptors upon food intake in rats under freely-feeding, deprivation and glucoprivic conditions. B-FNA elicited distinct short-term and long-term actions, consistent with binding studies demonstrating its reversible κ agonist actions and its irreversible μ receptor blockade. Whereas B-FNA (1–20 μg, i.c.v.) significantly stimulated free feeding for up to 6 h, B-FNA (10–20 μg) significantly inhibited (35–41%) free feeding at 24, 48 and 72 h after injection, a pattern temporally similar to its biochemical opioid effects. Pretreatment (24 h) with B-FNA (10–20 μg) significantly inhibited (33–49%) the increased intake following 24 h of food deprivation. Pretreatment (24 h) with B-FNA (10–20 μg) also significantly inhibited (75–100%) the increased glucoprivic intake induced by 2-deoxy-d-glucose. The short-term stimulation of food intake by central B-FNA was antagonized by the selective κ antagonist, nor-binaltorphamine, but was unaffected by pretreatment 24 h earlier with the μ antagonist, B-FNA. Significant reductions in striatal (89%) and hypothalamic (46%) μ-opioid binding occurred in rats pretreated (24 h) with B-FNA; the low levels of δ binding in these structures precluded interpretation of B-FNA effects. These data indicate the importance of the μ-opioid receptor in the modulation of different forms of feeding behavior, and underscores the ability of selective opioid antagonists to delineate precise functional roles for different opioid receptor subtypes." @default.
• W2023622908 created "2016-06-24" @default.
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• W2023622908 date "1990-12-01" @default.
• W2023622908 modified "2023-10-11" @default.
• W2023622908 title "Reduction by central ß-funaltrexamine of food intake in rats under freely-feeding, deprivation and glucoprivic conditions" @default.
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• W2023622908 doi "https://doi.org/10.1016/0006-8993(90)91828-5" @default.
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