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- W2023623035 abstract "N-Nitrosopiperidine (NP) and a number of methylated derivatives were examined for mutagenicity in Saccharomyces cerevisiae. NP, 2-methyl-NP, 3-methyl-NP, 4-methyl-NP and 3,5-dimethyl-NP were mutagens when metabolic activation (rat-liver microsomes) was provided. 2,6-Dimethyl-NP was not a mutagen. The NPs giving a positive response stimulated forward mutation to canavanine resistance (CAN1 → can1) and reversion of the hisl-7 missense marker. Neither locus revertants nor suppressors of the lysl-1 ochre marker were induced, nor were revertants of the putative frameshift hom3–10." @default.
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- W2023623035 date "1978-01-01" @default.
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- W2023623035 title "Mutagenicity of methylated N-nitrosopiperidines in Saccharomyces cerevisiae" @default.
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- W2023623035 doi "https://doi.org/10.1016/0027-5107(78)90262-2" @default.
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