FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023631471> ?p ?o ?g. }

• W2023631471 endingPage "430" @default.
• W2023631471 startingPage "423" @default.
• W2023631471 abstract "Abstract The skeleton in its function of affording strength and support to the body is subject to differential mechanical loading which has been implicated to mediate some of its effects on bone formation via the insulin‐like growth factors (IGFs), which are important regulators of bone metabolism. We, therefore, sought to conduct the present study with the hypothesis that the skeletal site‐dependent differences in mechanical loading and other variables including stage of osteoblast differentiation would be associated with site‐specific differences in the production of the IGF system components. To test this hypothesis, conditioned media (CM) from normal human bone cells (control and IGF‐II–treated 48‐h cultures) from five different skeletal sites were obtained and assayed for IGF‐I, IGF‐II (following separation of IGF binding proteins [IGFBPs]), IGFBP‐3, IGFBP‐4, and IGFBP‐5 protein levels employing specific radioimmunoassays for each protein. IGF‐I levels were lower than any other IGF system component but were significantly different between the various sites tested. IGF‐II levels were greatest in the CM from mandibular cells, followed by calvarial and rib cells, and least in the marrow stromal cells. IGFBP‐3 levels were highest in the CM of vertebral cells and lowest in the CM of rib and mandibular cells. The relative abundance of IGFBP‐4 in decreasing order was observed in mandibular, calvarial, vertebral, rib, and stromal cells' CM. IGFBP‐5 was produced maximally by the calvarial cells, followed by the mandibular, vertebral, stromal, and rib cells. IGFBP‐4 appeared to be the IGF system component most abundantly produced by all the cell types from the skeletal sites tested. On a molar basis, the IGFBPs in general were estimated to be produced at a higher magnitude than the IGFs. These findings indicate that there are skeletal site‐dependent differences in the production of IGF system components and suggest that the regulation of bone metabolism may vary at the various skeletal sites." @default.
• W2023631471 created "2016-06-24" @default.
• W2023631471 creator A5024383216 @default.
• W2023631471 creator A5024984935 @default.
• W2023631471 creator A5029876277 @default.
• W2023631471 creator A5054497725 @default.
• W2023631471 creator A5062648807 @default.
• W2023631471 date "1997-03-01" @default.
• W2023631471 modified "2023-10-18" @default.
• W2023631471 title "Insulin-like Growth Factor (IGF)-I, -II, IGF Binding Proteins (IGFBP)−3, −4, and −5 Levels in the Conditioned Media of Normal Human Bone Cells Are Skeletal Site-Dependent" @default.
• W2023631471 cites W1527128964 @default.
• W2023631471 cites W1569741533 @default.
• W2023631471 cites W1775749144 @default.
• W2023631471 cites W1967709376 @default.
• W2023631471 cites W1975949772 @default.
• W2023631471 cites W1989689857 @default.
• W2023631471 cites W1989896792 @default.
• W2023631471 cites W1991392063 @default.
• W2023631471 cites W1999561771 @default.
• W2023631471 cites W2000520037 @default.
• W2023631471 cites W2004145355 @default.
• W2023631471 cites W2006345660 @default.
• W2023631471 cites W2007006137 @default.
• W2023631471 cites W2015843482 @default.
• W2023631471 cites W2017309664 @default.
• W2023631471 cites W2017530941 @default.
• W2023631471 cites W2036476977 @default.
• W2023631471 cites W2042713071 @default.
• W2023631471 cites W2063049842 @default.
• W2023631471 cites W2064910660 @default.
• W2023631471 cites W2066523609 @default.
• W2023631471 cites W2072462218 @default.
• W2023631471 cites W2075254346 @default.
• W2023631471 cites W2099056711 @default.
• W2023631471 cites W2101108802 @default.
• W2023631471 cites W2133725782 @default.
• W2023631471 cites W2150890416 @default.
• W2023631471 cites W4234008559 @default.
• W2023631471 cites W4234388378 @default.
• W2023631471 cites W4234802967 @default.
• W2023631471 cites W4235873556 @default.
• W2023631471 cites W4236128778 @default.
• W2023631471 cites W4241396447 @default.
• W2023631471 cites W4241469733 @default.
• W2023631471 cites W4249567721 @default.
• W2023631471 cites W4254079501 @default.
• W2023631471 cites W4256356268 @default.
• W2023631471 doi "https://doi.org/10.1359/jbmr.1997.12.3.423" @default.
• W2023631471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9076585" @default.
• W2023631471 hasPublicationYear "1997" @default.
• W2023631471 type Work @default.
• W2023631471 sameAs 2023631471 @default.
• W2023631471 citedByCount "76" @default.
• W2023631471 countsByYear W20236314712012 @default.
• W2023631471 countsByYear W20236314712013 @default.
• W2023631471 countsByYear W20236314712016 @default.
• W2023631471 countsByYear W20236314712018 @default.
• W2023631471 countsByYear W20236314712019 @default.
• W2023631471 countsByYear W20236314712022 @default.
• W2023631471 crossrefType "journal-article" @default.
• W2023631471 hasAuthorship W2023631471A5024383216 @default.
• W2023631471 hasAuthorship W2023631471A5024984935 @default.
• W2023631471 hasAuthorship W2023631471A5029876277 @default.
• W2023631471 hasAuthorship W2023631471A5054497725 @default.
• W2023631471 hasAuthorship W2023631471A5062648807 @default.
• W2023631471 hasBestOaLocation W20236314711 @default.
• W2023631471 hasConcept C105702510 @default.
• W2023631471 hasConcept C126322002 @default.
• W2023631471 hasConcept C134018914 @default.
• W2023631471 hasConcept C16930146 @default.
• W2023631471 hasConcept C170033053 @default.
• W2023631471 hasConcept C170493617 @default.
• W2023631471 hasConcept C176685330 @default.
• W2023631471 hasConcept C185592680 @default.
• W2023631471 hasConcept C18969341 @default.
• W2023631471 hasConcept C202751555 @default.
• W2023631471 hasConcept C2775960820 @default.
• W2023631471 hasConcept C2778260815 @default.
• W2023631471 hasConcept C2780007613 @default.
• W2023631471 hasConcept C2780378035 @default.
• W2023631471 hasConcept C2780689927 @default.
• W2023631471 hasConcept C55493867 @default.
• W2023631471 hasConcept C71924100 @default.
• W2023631471 hasConcept C86803240 @default.
• W2023631471 hasConceptScore W2023631471C105702510 @default.
• W2023631471 hasConceptScore W2023631471C126322002 @default.
• W2023631471 hasConceptScore W2023631471C134018914 @default.
• W2023631471 hasConceptScore W2023631471C16930146 @default.
• W2023631471 hasConceptScore W2023631471C170033053 @default.
• W2023631471 hasConceptScore W2023631471C170493617 @default.
• W2023631471 hasConceptScore W2023631471C176685330 @default.
• W2023631471 hasConceptScore W2023631471C185592680 @default.
• W2023631471 hasConceptScore W2023631471C18969341 @default.
• W2023631471 hasConceptScore W2023631471C202751555 @default.
• W2023631471 hasConceptScore W2023631471C2775960820 @default.
• W2023631471 hasConceptScore W2023631471C2778260815 @default.
• W2023631471 hasConceptScore W2023631471C2780007613 @default.
• W2023631471 hasConceptScore W2023631471C2780378035 @default.

• next