FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023631898> ?p ?o ?g. }

• W2023631898 endingPage "2468" @default.
• W2023631898 startingPage "2460" @default.
• W2023631898 abstract "Abstract Conventional methods for regulating the differentiation of stem cells are largely based on the use of biological agents such as growth factors. We hypothesize that stem cell differentiation could be driven by specific synthetic molecules. If true, this would offer the possibility of screening chemical libraries to develop pharmacological agents with improved efficacy. To test our hypothesis, we have determined which, if any, of the nuclear receptor superfamily might be involved in chondrogenesis. We used fluorescence-activated cell sorting, as well as quantitative polymerase chain reaction, to study expression of a range of nuclear receptors in the undifferentiated mesenchymal population and after growth factor-driven differentiation of these cells to chondrocytes. In this way, we identified retinoic acid receptor β (RARβ) as a potential pharmacological target. A low molecular weight synthetic inhibitor of the RARα and RARβ receptors was able to induce chondrogenic differentiation of mesenchymal stem cells derived from osteoarthritis patients, in the absence of serum and growth factors. Furthermore, the pathway is independent of SOX9 upregulation and does not lead to hypertrophy. When mesenchymal cells were seeded on to polyglycolic acid scaffolds and cultured with LE135, there was a dose-dependent formation of cartilage, demonstrated both histologically and by biochemical analysis of the collagen component of the extracellular matrix. These results demonstrate the feasibility of a pharmacological approach to the regulation of stem cell function. Disclosure of potential conflicts of interest is found at the end of this article." @default.
• W2023631898 created "2016-06-24" @default.
• W2023631898 creator A5005826314 @default.
• W2023631898 creator A5037441796 @default.
• W2023631898 creator A5055964226 @default.
• W2023631898 creator A5062058969 @default.
• W2023631898 creator A5085679994 @default.
• W2023631898 date "2007-07-05" @default.
• W2023631898 modified "2023-09-23" @default.
• W2023631898 title "Pharmacological Regulation of Adult Stem Cells: Chondrogenesis Can Be Induced Using a Synthetic Inhibitor of the Retinoic Acid Receptor" @default.
• W2023631898 cites W1544751778 @default.
• W2023631898 cites W1969798346 @default.
• W2023631898 cites W1971865836 @default.
• W2023631898 cites W1974370636 @default.
• W2023631898 cites W1982824831 @default.
• W2023631898 cites W1983057459 @default.
• W2023631898 cites W1983529894 @default.
• W2023631898 cites W2003867975 @default.
• W2023631898 cites W2004488501 @default.
• W2023631898 cites W2011693143 @default.
• W2023631898 cites W2014673628 @default.
• W2023631898 cites W2017621537 @default.
• W2023631898 cites W2022804076 @default.
• W2023631898 cites W2022825927 @default.
• W2023631898 cites W2023070796 @default.
• W2023631898 cites W2024805424 @default.
• W2023631898 cites W2042932723 @default.
• W2023631898 cites W2046232107 @default.
• W2023631898 cites W2049887484 @default.
• W2023631898 cites W2052356779 @default.
• W2023631898 cites W2073382627 @default.
• W2023631898 cites W2075236181 @default.
• W2023631898 cites W2087616911 @default.
• W2023631898 cites W2099407461 @default.
• W2023631898 cites W2106907374 @default.
• W2023631898 cites W2125361012 @default.
• W2023631898 cites W2132837491 @default.
• W2023631898 cites W2147953427 @default.
• W2023631898 cites W2149790590 @default.
• W2023631898 cites W2159999899 @default.
• W2023631898 cites W2170167935 @default.
• W2023631898 cites W2318882529 @default.
• W2023631898 cites W4211245603 @default.
• W2023631898 doi "https://doi.org/10.1634/stemcells.2007-0059" @default.
• W2023631898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17615267" @default.
• W2023631898 hasPublicationYear "2007" @default.
• W2023631898 type Work @default.
• W2023631898 sameAs 2023631898 @default.
• W2023631898 citedByCount "37" @default.
• W2023631898 countsByYear W20236318982012 @default.
• W2023631898 countsByYear W20236318982013 @default.
• W2023631898 countsByYear W20236318982014 @default.
• W2023631898 countsByYear W20236318982015 @default.
• W2023631898 countsByYear W20236318982016 @default.
• W2023631898 countsByYear W20236318982018 @default.
• W2023631898 countsByYear W20236318982020 @default.
• W2023631898 countsByYear W20236318982021 @default.
• W2023631898 countsByYear W20236318982023 @default.
• W2023631898 crossrefType "journal-article" @default.
• W2023631898 hasAuthorship W2023631898A5005826314 @default.
• W2023631898 hasAuthorship W2023631898A5037441796 @default.
• W2023631898 hasAuthorship W2023631898A5055964226 @default.
• W2023631898 hasAuthorship W2023631898A5062058969 @default.
• W2023631898 hasAuthorship W2023631898A5085679994 @default.
• W2023631898 hasBestOaLocation W20236318981 @default.
• W2023631898 hasConcept C104317684 @default.
• W2023631898 hasConcept C148738053 @default.
• W2023631898 hasConcept C1491633281 @default.
• W2023631898 hasConcept C189165786 @default.
• W2023631898 hasConcept C198826908 @default.
• W2023631898 hasConcept C2778630268 @default.
• W2023631898 hasConcept C2781121885 @default.
• W2023631898 hasConcept C28328180 @default.
• W2023631898 hasConcept C35496256 @default.
• W2023631898 hasConcept C55493867 @default.
• W2023631898 hasConcept C86803240 @default.
• W2023631898 hasConcept C95444343 @default.
• W2023631898 hasConceptScore W2023631898C104317684 @default.
• W2023631898 hasConceptScore W2023631898C148738053 @default.
• W2023631898 hasConceptScore W2023631898C1491633281 @default.
• W2023631898 hasConceptScore W2023631898C189165786 @default.
• W2023631898 hasConceptScore W2023631898C198826908 @default.
• W2023631898 hasConceptScore W2023631898C2778630268 @default.
• W2023631898 hasConceptScore W2023631898C2781121885 @default.
• W2023631898 hasConceptScore W2023631898C28328180 @default.
• W2023631898 hasConceptScore W2023631898C35496256 @default.
• W2023631898 hasConceptScore W2023631898C55493867 @default.
• W2023631898 hasConceptScore W2023631898C86803240 @default.
• W2023631898 hasConceptScore W2023631898C95444343 @default.
• W2023631898 hasIssue "10" @default.
• W2023631898 hasLocation W20236318981 @default.
• W2023631898 hasLocation W20236318982 @default.
• W2023631898 hasOpenAccess W2023631898 @default.
• W2023631898 hasPrimaryLocation W20236318981 @default.
• W2023631898 hasRelatedWork W1979204192 @default.
• W2023631898 hasRelatedWork W1998532049 @default.
• W2023631898 hasRelatedWork W2013214537 @default.
• W2023631898 hasRelatedWork W2038865847 @default.

• next