Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023635908> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2023635908 endingPage "74" @default.
- W2023635908 startingPage "69" @default.
- W2023635908 abstract "We have recently developed a liquid-chromatography (LC)-based sensor for the broad-spectrum antibiotic chloramphenicol which relies upon the displacement of a chloramphenicol (CAP) dye conjugate from a molecularly imprinted polymer by the drug. The sensor was immune to interference from various chloramphenicol derivatives and ≈60% as responsive to thiamphenicol (TAM), an almost identical analog. The system showed a linear response to the drug over the 3–1000 μg ml−1 range; it was therefore effective both below and above the therapeutic (10–20 μg/ml−1 serum range, being potentially toxic above 25 μg ml−1). The sensor effectively detected CAP extracted from serum with a 3σ detection limit of ca. 5 μg ml−1. We have further simplified the construction of the sensor by the use of an in-situ imprinting technique wherein the polymer is formed inside an LC column. These columns are far simpler to prepare and, although their characteristics are somewhat different, their performance is comparable with that of the bulk-polymerized materials. The capacity of the columns is significantly less than that of packed columns but their ability to separate TAM and CAP is slightly better. The best of these columns showed a fairly linear response (r2=0.95, n=3) for 0–30 μg ml−1 CAP with a detection limit of ca. 3 μg ml−1. The column also showed a linear (r2=0.96, n=3), although lesser response to TAM over a similar concentration range. As with the bulk-polymerized material, the system showed minimal response to the diacetyl derivative CAP-DA." @default.
- W2023635908 created "2016-06-24" @default.
- W2023635908 creator A5009012536 @default.
- W2023635908 creator A5019805925 @default.
- W2023635908 creator A5056244023 @default.
- W2023635908 creator A5078387402 @default.
- W2023635908 creator A5084657374 @default.
- W2023635908 date "1998-06-01" @default.
- W2023635908 modified "2023-10-17" @default.
- W2023635908 title "Chloramphenicol sensor based on an in situ imprinted polymer" @default.
- W2023635908 cites W1499862875 @default.
- W2023635908 cites W1988806907 @default.
- W2023635908 cites W1994973945 @default.
- W2023635908 cites W1995343542 @default.
- W2023635908 cites W2033139932 @default.
- W2023635908 cites W2041365548 @default.
- W2023635908 cites W2049564237 @default.
- W2023635908 cites W2057662494 @default.
- W2023635908 cites W2063836077 @default.
- W2023635908 cites W2064844702 @default.
- W2023635908 cites W2066755768 @default.
- W2023635908 cites W2068419519 @default.
- W2023635908 cites W2088843328 @default.
- W2023635908 cites W2089018984 @default.
- W2023635908 cites W2097214398 @default.
- W2023635908 cites W2103352542 @default.
- W2023635908 cites W2104544655 @default.
- W2023635908 cites W2129771469 @default.
- W2023635908 cites W2148845788 @default.
- W2023635908 cites W2228630933 @default.
- W2023635908 cites W2314955984 @default.
- W2023635908 doi "https://doi.org/10.1016/s0003-2670(98)00096-8" @default.
- W2023635908 hasPublicationYear "1998" @default.
- W2023635908 type Work @default.
- W2023635908 sameAs 2023635908 @default.
- W2023635908 citedByCount "57" @default.
- W2023635908 countsByYear W20236359082012 @default.
- W2023635908 countsByYear W20236359082013 @default.
- W2023635908 countsByYear W20236359082015 @default.
- W2023635908 countsByYear W20236359082016 @default.
- W2023635908 countsByYear W20236359082020 @default.
- W2023635908 countsByYear W20236359082021 @default.
- W2023635908 countsByYear W20236359082022 @default.
- W2023635908 countsByYear W20236359082023 @default.
- W2023635908 crossrefType "journal-article" @default.
- W2023635908 hasAuthorship W2023635908A5009012536 @default.
- W2023635908 hasAuthorship W2023635908A5019805925 @default.
- W2023635908 hasAuthorship W2023635908A5056244023 @default.
- W2023635908 hasAuthorship W2023635908A5078387402 @default.
- W2023635908 hasAuthorship W2023635908A5084657374 @default.
- W2023635908 hasConcept C10349863 @default.
- W2023635908 hasConcept C118792377 @default.
- W2023635908 hasConcept C119128265 @default.
- W2023635908 hasConcept C161790260 @default.
- W2023635908 hasConcept C162602672 @default.
- W2023635908 hasConcept C178790620 @default.
- W2023635908 hasConcept C185592680 @default.
- W2023635908 hasConcept C2777728207 @default.
- W2023635908 hasConcept C2778473333 @default.
- W2023635908 hasConcept C39442485 @default.
- W2023635908 hasConcept C43617362 @default.
- W2023635908 hasConcept C501593827 @default.
- W2023635908 hasConcept C521977710 @default.
- W2023635908 hasConcept C55493867 @default.
- W2023635908 hasConceptScore W2023635908C10349863 @default.
- W2023635908 hasConceptScore W2023635908C118792377 @default.
- W2023635908 hasConceptScore W2023635908C119128265 @default.
- W2023635908 hasConceptScore W2023635908C161790260 @default.
- W2023635908 hasConceptScore W2023635908C162602672 @default.
- W2023635908 hasConceptScore W2023635908C178790620 @default.
- W2023635908 hasConceptScore W2023635908C185592680 @default.
- W2023635908 hasConceptScore W2023635908C2777728207 @default.
- W2023635908 hasConceptScore W2023635908C2778473333 @default.
- W2023635908 hasConceptScore W2023635908C39442485 @default.
- W2023635908 hasConceptScore W2023635908C43617362 @default.
- W2023635908 hasConceptScore W2023635908C501593827 @default.
- W2023635908 hasConceptScore W2023635908C521977710 @default.
- W2023635908 hasConceptScore W2023635908C55493867 @default.
- W2023635908 hasFunder F4320320912 @default.
- W2023635908 hasIssue "1-3" @default.
- W2023635908 hasLocation W20236359081 @default.
- W2023635908 hasOpenAccess W2023635908 @default.
- W2023635908 hasPrimaryLocation W20236359081 @default.
- W2023635908 hasRelatedWork W1940744239 @default.
- W2023635908 hasRelatedWork W1965930423 @default.
- W2023635908 hasRelatedWork W2022445948 @default.
- W2023635908 hasRelatedWork W2089718673 @default.
- W2023635908 hasRelatedWork W2116081071 @default.
- W2023635908 hasRelatedWork W2150050937 @default.
- W2023635908 hasRelatedWork W2345074326 @default.
- W2023635908 hasRelatedWork W2351083671 @default.
- W2023635908 hasRelatedWork W2355950030 @default.
- W2023635908 hasRelatedWork W2463138449 @default.
- W2023635908 hasVolume "365" @default.
- W2023635908 isParatext "false" @default.
- W2023635908 isRetracted "false" @default.
- W2023635908 magId "2023635908" @default.
- W2023635908 workType "article" @default.