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- W2023638279 abstract "The synthesis of ten 11C-labeled aromatic and aliphatic guanidines in supercritical ammonia is described. The corresponding amines were first converted into cyanamides by reaction with [11C]cyanogen bromide. The aliphatic amines gave high yields of 11C-labeled cyanamides (70−98%), whereas the yields for the aromatic amines was dependent on the functional groups on the ring, ranging from 0% yield for the electron-withdrawing nitro group to 90% for the electron-donating methoxy group. The conversion of the 11C-labeled cyanamides to 11C-labeled guanidines was achieved in both supercritical ammonia and aqueous ammonia solutions. The latter method gave low and irreproducible yields as compared to performing the reactions in an automated supercritical fluid synthesis (SFS) system (designed for use with supercritical ammonia). Using the SFS system, total radiochemical yields of 11C-labeled guanidines of 30−85% were obtained from the aromatic amines (depending on the substituents) and 2−36% for the aliphatic amines. A simultaneous synthesis of 11/13C-labeled phenylguanidine was performed to verify the labeling position by comparing the 13C-NMR of the labelled product to authentic reference compound." @default.
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- W2023638279 date "1996-01-01" @default.
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- W2023638279 title "Synthesis of <sup>11</sup>C-Labeled Guanidines in Supercritical Ammonia" @default.
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- W2023638279 doi "https://doi.org/10.1021/ja960667e" @default.
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