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- W2023642835 abstract "Abstract 5,6,7,8-Tetrahydrobiopterin (BH 4 ) is an csscntial cofactor for production of nitric oxide (NO) by N O synthase (NOS). Nitric oxide (NO) is an important signaling mo!ecu!e for the regulation o f vita! functions such as vascular tone, neurotransmission and immune surveiüance. Accumu!ated evidences show that although NOS mainly re!eases N O under nonnal conditions, NOS also produces Superoxide anion and hydrogen peroxide when BH 4 is decreased, suggesting the possibility that NOS is a source of reactive oxygen species (ROS) under pathological conditions. In fact, supplementation of BH 4 restores N O production and availability in various diseases including hyperlipidemia, diabetes, hypertension and ischemia-reperfusion. Moreover, recent studies show that administration o f BH 4 protects tissues against ischemia-reperfusion injuiy in heart, stomach and liver. Oxidative stress is a common mechanism underlying the development of vascular diseases and reperfusion injury. Regulation of BH 4 levels under oxidative stress is important to understand the role of BH 4 on the development of vascular diseases and reperfusion injury. We recently described that oxidative stress transiently decreased BH 4 levels, and then markedly increased its levels in vascular endothelial cells. Supplementation of BH 4 appears to be important therapeutic strategies in vascular diseases and reperfusion injury, and induction of BH 4 synthesis may endogenous defense system against oxidative stress-mediated cardiovascular diseases." @default.
- W2023642835 created "2016-06-24" @default.
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- W2023642835 date "2006-02-01" @default.
- W2023642835 modified "2023-09-28" @default.
- W2023642835 title "Beneficial Role of Tetrahydrobiopterin on Various Cardiovascular Diseases and Regulation of its Levels under Pathological Conditions" @default.
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- W2023642835 doi "https://doi.org/10.1515/pteridines.2006.17.1.5" @default.
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