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- W2023642943 abstract "This paper develops a simplified analytical solution for the slow axonal transport of tau proteins. A six kinetic state model developed in Jung and Brown [1] was used to simulate transport of tau. The model was extended by accounting for tau degradation and diffusion in the off-track kinetic states. The analytical solution was obtained by assuming that transitions between anterograde and retrograde states are infrequent. This assumption was validated through an analysis of the sensitivity of the solution to changes in the values of the two kinetic constants that describe the transition rates between the anterograde and retrograde states, and by a comparison with the experimentally measured tau distributions reported in Konzack et al. [2]. The predicted average transport velocity of tau was also in the experimentally reported range." @default.
- W2023642943 created "2016-06-24" @default.
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- W2023642943 date "2013-11-15" @default.
- W2023642943 modified "2023-09-27" @default.
- W2023642943 title "Modeling of Tau Protein Transport in Axons" @default.
- W2023642943 doi "https://doi.org/10.1115/imece2013-62430" @default.
- W2023642943 hasPublicationYear "2013" @default.
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