FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023642970> ?p ?o ?g. }

• W2023642970 endingPage "1240" @default.
• W2023642970 startingPage "1237" @default.
• W2023642970 abstract "Localization of the anatomic substrate for anticonvulsant activity mediated by gamma-aminobutyric acid (GABA) was examined using intracerebral injections of GABA agonists. Blockade of tonic hindlimb extension in the maximal electroshock test and blockade of tonic and clonic seizures produced by pentylenetetrazole and bicuculline were obtained by elevating GABA in the ventral midbrain tegmentum. Elevation of GABA in forebrain and hindbrain areas had no effect on convulsant activity. Blockade of tonic and clonic seizures was also obtained after microinjections of the direct GABA receptor agonist, muscimol, into the midbrain. The substantia nigra was identified as the critical midbrain site for GABA-mediated anticonvulsant activity. Local injection of GABA agonists into the midbrain provided seizure protection without a widespread augmentation of GABA-mediated activity throughout the brain and without impairing either alertness or motor function. Synapses in the substantia nigra appear to represent an important control mechanism for inhibiting the propagation of generalized convulsions." @default.
• W2023642970 created "2016-06-24" @default.
• W2023642970 creator A5006333981 @default.
• W2023642970 creator A5083210265 @default.
• W2023642970 date "1982-12-17" @default.
• W2023642970 modified "2023-10-11" @default.
• W2023642970 title "Substantia Nigra: Site of Anticonvulsant Activity Mediated by γ-Aminobutyric Acid" @default.
• W2023642970 cites W1152299788 @default.
• W2023642970 cites W1964215857 @default.
• W2023642970 cites W1976363405 @default.
• W2023642970 cites W1977221546 @default.
• W2023642970 cites W1979509950 @default.
• W2023642970 cites W1992603366 @default.
• W2023642970 cites W1994695196 @default.
• W2023642970 cites W2002130434 @default.
• W2023642970 cites W2009262335 @default.
• W2023642970 cites W2016968166 @default.
• W2023642970 cites W2021661569 @default.
• W2023642970 cites W2022576226 @default.
• W2023642970 cites W2028864767 @default.
• W2023642970 cites W2064478417 @default.
• W2023642970 cites W2076847916 @default.
• W2023642970 cites W2159026414 @default.
• W2023642970 cites W2167324562 @default.
• W2023642970 cites W2315169175 @default.
• W2023642970 cites W2409788190 @default.
• W2023642970 doi "https://doi.org/10.1126/science.7146907" @default.
• W2023642970 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7146907" @default.
• W2023642970 hasPublicationYear "1982" @default.
• W2023642970 type Work @default.
• W2023642970 sameAs 2023642970 @default.
• W2023642970 citedByCount "589" @default.
• W2023642970 countsByYear W20236429702012 @default.
• W2023642970 countsByYear W20236429702013 @default.
• W2023642970 countsByYear W20236429702014 @default.
• W2023642970 countsByYear W20236429702015 @default.
• W2023642970 countsByYear W20236429702016 @default.
• W2023642970 countsByYear W20236429702017 @default.
• W2023642970 countsByYear W20236429702018 @default.
• W2023642970 countsByYear W20236429702019 @default.
• W2023642970 countsByYear W20236429702020 @default.
• W2023642970 countsByYear W20236429702021 @default.
• W2023642970 countsByYear W20236429702022 @default.
• W2023642970 countsByYear W20236429702023 @default.
• W2023642970 crossrefType "journal-article" @default.
• W2023642970 hasAuthorship W2023642970A5006333981 @default.
• W2023642970 hasAuthorship W2023642970A5083210265 @default.
• W2023642970 hasConcept C126322002 @default.
• W2023642970 hasConcept C127573956 @default.
• W2023642970 hasConcept C134018914 @default.
• W2023642970 hasConcept C137183658 @default.
• W2023642970 hasConcept C168258287 @default.
• W2023642970 hasConcept C169760540 @default.
• W2023642970 hasConcept C170493617 @default.
• W2023642970 hasConcept C185592680 @default.
• W2023642970 hasConcept C24566897 @default.
• W2023642970 hasConcept C2775858608 @default.
• W2023642970 hasConcept C2776674594 @default.
• W2023642970 hasConcept C2778186239 @default.
• W2023642970 hasConcept C2779188335 @default.
• W2023642970 hasConcept C2779715522 @default.
• W2023642970 hasConcept C2780763569 @default.
• W2023642970 hasConcept C2780938664 @default.
• W2023642970 hasConcept C513476851 @default.
• W2023642970 hasConcept C529278444 @default.
• W2023642970 hasConcept C552161191 @default.
• W2023642970 hasConcept C71924100 @default.
• W2023642970 hasConcept C79636183 @default.
• W2023642970 hasConcept C86803240 @default.
• W2023642970 hasConcept C98274493 @default.
• W2023642970 hasConceptScore W2023642970C126322002 @default.
• W2023642970 hasConceptScore W2023642970C127573956 @default.
• W2023642970 hasConceptScore W2023642970C134018914 @default.
• W2023642970 hasConceptScore W2023642970C137183658 @default.
• W2023642970 hasConceptScore W2023642970C168258287 @default.
• W2023642970 hasConceptScore W2023642970C169760540 @default.
• W2023642970 hasConceptScore W2023642970C170493617 @default.
• W2023642970 hasConceptScore W2023642970C185592680 @default.
• W2023642970 hasConceptScore W2023642970C24566897 @default.
• W2023642970 hasConceptScore W2023642970C2775858608 @default.
• W2023642970 hasConceptScore W2023642970C2776674594 @default.
• W2023642970 hasConceptScore W2023642970C2778186239 @default.
• W2023642970 hasConceptScore W2023642970C2779188335 @default.
• W2023642970 hasConceptScore W2023642970C2779715522 @default.
• W2023642970 hasConceptScore W2023642970C2780763569 @default.
• W2023642970 hasConceptScore W2023642970C2780938664 @default.
• W2023642970 hasConceptScore W2023642970C513476851 @default.
• W2023642970 hasConceptScore W2023642970C529278444 @default.
• W2023642970 hasConceptScore W2023642970C552161191 @default.
• W2023642970 hasConceptScore W2023642970C71924100 @default.
• W2023642970 hasConceptScore W2023642970C79636183 @default.
• W2023642970 hasConceptScore W2023642970C86803240 @default.
• W2023642970 hasConceptScore W2023642970C98274493 @default.
• W2023642970 hasIssue "4578" @default.
• W2023642970 hasLocation W20236429701 @default.
• W2023642970 hasLocation W20236429702 @default.
• W2023642970 hasOpenAccess W2023642970 @default.
• W2023642970 hasPrimaryLocation W20236429701 @default.

• next