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- W2023644519 endingPage "1167" @default.
- W2023644519 startingPage "1161" @default.
- W2023644519 abstract "Les hormones ou neurotransmetteurs agissant au niveau de leur cellule cible en augmentant la concentration de calcium cytosolique stimulent aussi dans tous les cas l'hydrolyse des polyphosphoinositol lipides. De nombreux arguments suggèrent que 1) cette réaction résulte de la fixation de l'hormone ou du neurotransmetteur sur son récepteur et 2) qu'elle provoque la mobilisation du calcium intracellulaire. Des résultats récents obtenus sur deux types cellulaires: l'hépatocyte et les cellules WRK-1, indiquent que l'étape primaire induite par la liaison de l'hormone sur son récepteur est une hydrolyse du phosphatidylinositol 4,5-biphosphate. L'inositol triphosphate et le diacylglycérol libérés représentent vraisemblablement les intermédiaires intracellulaires de l'hormone impliqués dans l'action de celle-ci. All hormones and neurotransmitters which provoke their intracellular effects by increasing the cytosolic concentration of Ca2+ in their target cells also stimulate the breakdown of inositol phospholipids. Much evidence suggests that this breakdown is intimately involved in the mechanism which couples cell-surface receptor activation to intracellular Ca2+ mobilization. Recent results indicate that the primary, receptor-mediated event in stimulated cells is a phosphodiesteric hydrolysis of phosphatidylinositol 4,5-bisphosphate to yield inositol trisphosphate and diacylglycerol. It is likely that both products of this reaction fulfill ‘second messenger’ roles within stimulated cells." @default.
- W2023644519 created "2016-06-24" @default.
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- W2023644519 date "1985-10-01" @default.
- W2023644519 modified "2023-10-01" @default.
- W2023644519 title "Hormone-mediated inositol lipid breakdown in hepatocytes and WRK1 cells: relationship to receptor function" @default.
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- W2023644519 doi "https://doi.org/10.1016/s0300-9084(85)80115-2" @default.
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