FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023646532> ?p ?o ?g. }

• W2023646532 endingPage "568" @default.
• W2023646532 startingPage "556" @default.
• W2023646532 abstract "In cardiovascular research, relaxation and stiffness are calculated from pressure-volume (PV) curves by separately fitting the data during the isovolumic and end-diastolic phases (end-diastolic PV relationship), respectively. This method is limited because it assumes uncoupled active and passive properties during these phases, it penalizes statistical power, and it cannot account for elastic restoring forces. We aimed to improve this analysis by implementing a method based on global optimization of all PV diastolic data. In 1,000 Monte Carlo experiments, the optimization algorithm recovered entered parameters of diastolic properties below and above the equilibrium volume (intraclass correlation coefficients = 0.99). Inotropic modulation experiments in 26 pigs modified passive pressure generated by restoring forces due to changes in the operative and/or equilibrium volumes. Volume overload and coronary microembolization caused incomplete relaxation at end diastole (active pressure > 0.5 mmHg), rendering the end-diastolic PV relationship method ill-posed. In 28 patients undergoing PV cardiac catheterization, the new algorithm reduced the confidence intervals of stiffness parameters by one-fifth. The Jacobian matrix allowed visualizing the contribution of each property to instantaneous diastolic pressure on a per-patient basis. The algorithm allowed estimating stiffness from single-beat PV data (derivative of left ventricular pressure with respect to volume at end-diastolic volume intraclass correlation coefficient = 0.65, error = 0.07 ± 0.24 mmHg/ml). Thus, in clinical and preclinical research, global optimization algorithms provide the most complete, accurate, and reproducible assessment of global left ventricular diastolic chamber properties from PV data. Using global optimization, we were able to fully uncouple relaxation and passive PV curves for the first time in the intact heart." @default.
• W2023646532 created "2016-06-24" @default.
• W2023646532 creator A5001870154 @default.
• W2023646532 creator A5015772726 @default.
• W2023646532 creator A5021404852 @default.
• W2023646532 creator A5025734951 @default.
• W2023646532 creator A5027611017 @default.
• W2023646532 creator A5029565374 @default.
• W2023646532 creator A5057715381 @default.
• W2023646532 creator A5060725463 @default.
• W2023646532 creator A5061145924 @default.
• W2023646532 creator A5061541091 @default.
• W2023646532 creator A5075123470 @default.
• W2023646532 creator A5083608927 @default.
• W2023646532 creator A5087490208 @default.
• W2023646532 date "2013-08-15" @default.
• W2023646532 modified "2023-10-18" @default.
• W2023646532 title "Diastolic chamber properties of the left ventricle assessed by global fitting of pressure-volume data: improving the gold standard of diastolic function" @default.
• W2023646532 cites W166951484 @default.
• W2023646532 cites W177304574 @default.
• W2023646532 cites W1787686439 @default.
• W2023646532 cites W1885246557 @default.
• W2023646532 cites W1942977593 @default.
• W2023646532 cites W1970185852 @default.
• W2023646532 cites W1971420588 @default.
• W2023646532 cites W1972241757 @default.
• W2023646532 cites W1985005740 @default.
• W2023646532 cites W1999442547 @default.
• W2023646532 cites W2008824074 @default.
• W2023646532 cites W2021479382 @default.
• W2023646532 cites W2023785505 @default.
• W2023646532 cites W2051315781 @default.
• W2023646532 cites W2054876138 @default.
• W2023646532 cites W2061740412 @default.
• W2023646532 cites W2062414497 @default.
• W2023646532 cites W2071325925 @default.
• W2023646532 cites W2081269723 @default.
• W2023646532 cites W2083617799 @default.
• W2023646532 cites W2091360003 @default.
• W2023646532 cites W2091807643 @default.
• W2023646532 cites W2097063884 @default.
• W2023646532 cites W2104351484 @default.
• W2023646532 cites W2105026953 @default.
• W2023646532 cites W2109281287 @default.
• W2023646532 cites W2111359734 @default.
• W2023646532 cites W2119051431 @default.
• W2023646532 cites W2125138738 @default.
• W2023646532 cites W2137784332 @default.
• W2023646532 cites W2139689740 @default.
• W2023646532 cites W2149757185 @default.
• W2023646532 cites W2150682881 @default.
• W2023646532 cites W2150888479 @default.
• W2023646532 cites W2151802250 @default.
• W2023646532 cites W2161390320 @default.
• W2023646532 cites W2170484057 @default.
• W2023646532 cites W2403670870 @default.
• W2023646532 cites W2546757355 @default.
• W2023646532 cites W3022179669 @default.
• W2023646532 cites W70054044 @default.
• W2023646532 cites W71322121 @default.
• W2023646532 doi "https://doi.org/10.1152/japplphysiol.00363.2013" @default.
• W2023646532 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3742944" @default.
• W2023646532 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23743396" @default.
• W2023646532 hasPublicationYear "2013" @default.
• W2023646532 type Work @default.
• W2023646532 sameAs 2023646532 @default.
• W2023646532 citedByCount "17" @default.
• W2023646532 countsByYear W20236465322015 @default.
• W2023646532 countsByYear W20236465322016 @default.
• W2023646532 countsByYear W20236465322017 @default.
• W2023646532 countsByYear W20236465322019 @default.
• W2023646532 countsByYear W20236465322020 @default.
• W2023646532 countsByYear W20236465322023 @default.
• W2023646532 crossrefType "journal-article" @default.
• W2023646532 hasAuthorship W2023646532A5001870154 @default.
• W2023646532 hasAuthorship W2023646532A5015772726 @default.
• W2023646532 hasAuthorship W2023646532A5021404852 @default.
• W2023646532 hasAuthorship W2023646532A5025734951 @default.
• W2023646532 hasAuthorship W2023646532A5027611017 @default.
• W2023646532 hasAuthorship W2023646532A5029565374 @default.
• W2023646532 hasAuthorship W2023646532A5057715381 @default.
• W2023646532 hasAuthorship W2023646532A5060725463 @default.
• W2023646532 hasAuthorship W2023646532A5061145924 @default.
• W2023646532 hasAuthorship W2023646532A5061541091 @default.
• W2023646532 hasAuthorship W2023646532A5075123470 @default.
• W2023646532 hasAuthorship W2023646532A5083608927 @default.
• W2023646532 hasAuthorship W2023646532A5087490208 @default.
• W2023646532 hasBestOaLocation W20236465322 @default.
• W2023646532 hasConcept C104709138 @default.
• W2023646532 hasConcept C105795698 @default.
• W2023646532 hasConcept C126322002 @default.
• W2023646532 hasConcept C164705383 @default.
• W2023646532 hasConcept C26635844 @default.
• W2023646532 hasConcept C2778921608 @default.
• W2023646532 hasConcept C33923547 @default.
• W2023646532 hasConcept C57900726 @default.
• W2023646532 hasConcept C71924100 @default.
• W2023646532 hasConcept C84393581 @default.

• next