Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023646633> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W2023646633 endingPage "10957" @default.
- W2023646633 startingPage "10950" @default.
- W2023646633 abstract "The binding of a macrocyclic bisacridine and an antitumor intercalator ametantrone to DNA has been studied. We carried out X-ray diffraction analyses of the complexes between both intercalators and CGTACG. We have determined the crystal structure, by the multiple-wavelength anomalous diffraction (MAD) method, of bisacridine complexed with CGTA[br5C]G at 1.8 Å resolution. The refined native crystal structure at 1.1 Å resolution (space group C222, a = 29.58 Å, b = 54.04 Å, c = 40.22 Å, and R-factor = 0.163) revealed that only one acridine of the bisacridine drug binds at the C5pG6 step of the DNA, with the other acridine plus both linkers completely disordered. Surprisingly, both terminal G·C base pairs are unraveled. The C1 nucleotide is disordered, and the G2 base is bridged to its own phosphate P2 through a hydrated Co2+ ion. G12 is swung toward the minor groove with its base stacked over the backbone. The C7 nucleotide is flipped away from the duplex part and base paired to a 2-fold symmetry-related G6*. The central four base pairs adopt the B-DNA conformation. An unusual intercalator platform is formed by bringing four complexes together (involving the 222 symmetry) such that the intercalator cavity is flanked by two sets of G·C base pairs (i.e., C5·G8 and G6·C7*) on each side, joined together by G6·G8* tertiary base pairing interactions. In the bisacridine−CGTACG complex, the intercalation platform is intercalated with two acridines, whereas in the ametantrone−CGTACG complex, only one ametantrone is bound. NMR titration of the bisacridine to AACGATCGTT suggests that the bisacridine prefers to bridge more than one DNA duplex by intercalating each acridine to different duplexes. The results may be relevant in understanding binding of certain intercalators to DNA structure associated with the quadruplet helix and Holliday junction." @default.
- W2023646633 created "2016-06-24" @default.
- W2023646633 creator A5002688120 @default.
- W2023646633 creator A5016567722 @default.
- W2023646633 creator A5066032480 @default.
- W2023646633 creator A5078223433 @default.
- W2023646633 date "2000-08-17" @default.
- W2023646633 modified "2023-09-24" @default.
- W2023646633 title "Binding of a Macrocyclic Bisacridine and Ametantrone to CGTACG Involves Similar Unusual Intercalation Platforms" @default.
- W2023646633 cites W1971022951 @default.
- W2023646633 cites W1971881975 @default.
- W2023646633 cites W1972476994 @default.
- W2023646633 cites W2044902178 @default.
- W2023646633 cites W2081404961 @default.
- W2023646633 cites W2115136437 @default.
- W2023646633 cites W2334601667 @default.
- W2023646633 doi "https://doi.org/10.1021/bi001319z" @default.
- W2023646633 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10998231" @default.
- W2023646633 hasPublicationYear "2000" @default.
- W2023646633 type Work @default.
- W2023646633 sameAs 2023646633 @default.
- W2023646633 citedByCount "35" @default.
- W2023646633 countsByYear W20236466332012 @default.
- W2023646633 countsByYear W20236466332013 @default.
- W2023646633 countsByYear W20236466332016 @default.
- W2023646633 countsByYear W20236466332017 @default.
- W2023646633 countsByYear W20236466332020 @default.
- W2023646633 countsByYear W20236466332022 @default.
- W2023646633 crossrefType "journal-article" @default.
- W2023646633 hasAuthorship W2023646633A5002688120 @default.
- W2023646633 hasAuthorship W2023646633A5016567722 @default.
- W2023646633 hasAuthorship W2023646633A5066032480 @default.
- W2023646633 hasAuthorship W2023646633A5078223433 @default.
- W2023646633 hasConcept C104317684 @default.
- W2023646633 hasConcept C115624301 @default.
- W2023646633 hasConcept C137824038 @default.
- W2023646633 hasConcept C178790620 @default.
- W2023646633 hasConcept C179104552 @default.
- W2023646633 hasConcept C185581394 @default.
- W2023646633 hasConcept C185592680 @default.
- W2023646633 hasConcept C2776924795 @default.
- W2023646633 hasConcept C512185932 @default.
- W2023646633 hasConcept C552990157 @default.
- W2023646633 hasConcept C55493867 @default.
- W2023646633 hasConcept C61234307 @default.
- W2023646633 hasConcept C71240020 @default.
- W2023646633 hasConcept C8010536 @default.
- W2023646633 hasConceptScore W2023646633C104317684 @default.
- W2023646633 hasConceptScore W2023646633C115624301 @default.
- W2023646633 hasConceptScore W2023646633C137824038 @default.
- W2023646633 hasConceptScore W2023646633C178790620 @default.
- W2023646633 hasConceptScore W2023646633C179104552 @default.
- W2023646633 hasConceptScore W2023646633C185581394 @default.
- W2023646633 hasConceptScore W2023646633C185592680 @default.
- W2023646633 hasConceptScore W2023646633C2776924795 @default.
- W2023646633 hasConceptScore W2023646633C512185932 @default.
- W2023646633 hasConceptScore W2023646633C552990157 @default.
- W2023646633 hasConceptScore W2023646633C55493867 @default.
- W2023646633 hasConceptScore W2023646633C61234307 @default.
- W2023646633 hasConceptScore W2023646633C71240020 @default.
- W2023646633 hasConceptScore W2023646633C8010536 @default.
- W2023646633 hasIssue "36" @default.
- W2023646633 hasLocation W20236466331 @default.
- W2023646633 hasLocation W20236466332 @default.
- W2023646633 hasOpenAccess W2023646633 @default.
- W2023646633 hasPrimaryLocation W20236466331 @default.
- W2023646633 hasRelatedWork W1858609664 @default.
- W2023646633 hasRelatedWork W1976031446 @default.
- W2023646633 hasRelatedWork W1981974630 @default.
- W2023646633 hasRelatedWork W1982412721 @default.
- W2023646633 hasRelatedWork W2023646633 @default.
- W2023646633 hasRelatedWork W2161546495 @default.
- W2023646633 hasRelatedWork W2418616204 @default.
- W2023646633 hasRelatedWork W2745426438 @default.
- W2023646633 hasRelatedWork W3194965243 @default.
- W2023646633 hasRelatedWork W4213352267 @default.
- W2023646633 hasVolume "39" @default.
- W2023646633 isParatext "false" @default.
- W2023646633 isRetracted "false" @default.
- W2023646633 magId "2023646633" @default.
- W2023646633 workType "article" @default.