FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023646680> ?p ?o ?g. }

• W2023646680 endingPage "2706" @default.
• W2023646680 startingPage "2678" @default.
• W2023646680 abstract "Synthetic biology has recently provided functional single-cell oscillators. With a few exceptions, however, synchronization across a population has not been achieved yet. In particular, designing a cell coupling mechanism to achieve autonomous synchronization is not straightforward since there are usually several different design alternatives. Here, we propose a method to mathematically predict autonomous synchronization properties, and to identify the network structure with the best performance, thus increasing the feasibility for a successful implementation in vivo. Our method relies on the reduction of ODE-based models for synthetic oscillators to a phase description, and the subsequent analysis of the phase model either in the spatially homogeneous or heterogeneous case. This analysis identifies three major factors determining if and when autonomous synchronization can be achieved, namely cell density, cell to cell variability, and structural design decisions. Moreover, when considering a spatially heterogeneous medium, we observe phase waves. These waves may hinder synchronization substantially, and their suppression should be considered in the design process. In contrast to previous work, we analyze the synchronization process of models of experimentally validated synthetic oscillators in mammalian cells. Alternative designs for cell-to-cell communication via a quorum sensing mechanism differ in few mechanistic details, but these differences have important implications for autonomous synchronization. Our analysis suggests that not only the periodical transcription of the protein producing the signaling molecule, but also of the receptor protein is necessary to achieve good performance." @default.
• W2023646680 created "2016-06-24" @default.
• W2023646680 creator A5021804106 @default.
• W2023646680 creator A5038054569 @default.
• W2023646680 creator A5042243195 @default.
• W2023646680 creator A5085247534 @default.
• W2023646680 date "2011-03-04" @default.
• W2023646680 modified "2023-10-01" @default.
• W2023646680 title "Autonomous Synchronization of Chemically Coupled Synthetic Oscillators" @default.
• W2023646680 cites W111157985 @default.
• W2023646680 cites W1645305843 @default.
• W2023646680 cites W1963493422 @default.
• W2023646680 cites W1970768185 @default.
• W2023646680 cites W1992306462 @default.
• W2023646680 cites W2007769474 @default.
• W2023646680 cites W2018314770 @default.
• W2023646680 cites W2027267866 @default.
• W2023646680 cites W2028710062 @default.
• W2023646680 cites W2030083295 @default.
• W2023646680 cites W2034434606 @default.
• W2023646680 cites W2063778415 @default.
• W2023646680 cites W2070312290 @default.
• W2023646680 cites W2070326559 @default.
• W2023646680 cites W2104290916 @default.
• W2023646680 cites W2114228460 @default.
• W2023646680 cites W2117360286 @default.
• W2023646680 cites W2123097315 @default.
• W2023646680 cites W2126841507 @default.
• W2023646680 cites W2130518506 @default.
• W2023646680 cites W2131050167 @default.
• W2023646680 cites W2131869707 @default.
• W2023646680 cites W2132828256 @default.
• W2023646680 cites W2148956121 @default.
• W2023646680 cites W2165861322 @default.
• W2023646680 cites W2166860637 @default.
• W2023646680 cites W2499343420 @default.
• W2023646680 cites W3102501184 @default.
• W2023646680 cites W4297978922 @default.
• W2023646680 doi "https://doi.org/10.1007/s11538-011-9642-8" @default.
• W2023646680 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21373974" @default.
• W2023646680 hasPublicationYear "2011" @default.
• W2023646680 type Work @default.
• W2023646680 sameAs 2023646680 @default.
• W2023646680 citedByCount "8" @default.
• W2023646680 countsByYear W20236466802012 @default.
• W2023646680 countsByYear W20236466802014 @default.
• W2023646680 countsByYear W20236466802015 @default.
• W2023646680 countsByYear W20236466802018 @default.
• W2023646680 countsByYear W20236466802022 @default.
• W2023646680 crossrefType "journal-article" @default.
• W2023646680 hasAuthorship W2023646680A5021804106 @default.
• W2023646680 hasAuthorship W2023646680A5038054569 @default.
• W2023646680 hasAuthorship W2023646680A5042243195 @default.
• W2023646680 hasAuthorship W2023646680A5085247534 @default.
• W2023646680 hasBestOaLocation W20236466802 @default.
• W2023646680 hasConcept C111097370 @default.
• W2023646680 hasConcept C111919701 @default.
• W2023646680 hasConcept C114614502 @default.
• W2023646680 hasConcept C120314980 @default.
• W2023646680 hasConcept C127162648 @default.
• W2023646680 hasConcept C184720557 @default.
• W2023646680 hasConcept C186060115 @default.
• W2023646680 hasConcept C191908910 @default.
• W2023646680 hasConcept C2778562939 @default.
• W2023646680 hasConcept C28826006 @default.
• W2023646680 hasConcept C33923547 @default.
• W2023646680 hasConcept C34862557 @default.
• W2023646680 hasConcept C41008148 @default.
• W2023646680 hasConcept C60644358 @default.
• W2023646680 hasConcept C76155785 @default.
• W2023646680 hasConcept C86803240 @default.
• W2023646680 hasConcept C98045186 @default.
• W2023646680 hasConceptScore W2023646680C111097370 @default.
• W2023646680 hasConceptScore W2023646680C111919701 @default.
• W2023646680 hasConceptScore W2023646680C114614502 @default.
• W2023646680 hasConceptScore W2023646680C120314980 @default.
• W2023646680 hasConceptScore W2023646680C127162648 @default.
• W2023646680 hasConceptScore W2023646680C184720557 @default.
• W2023646680 hasConceptScore W2023646680C186060115 @default.
• W2023646680 hasConceptScore W2023646680C191908910 @default.
• W2023646680 hasConceptScore W2023646680C2778562939 @default.
• W2023646680 hasConceptScore W2023646680C28826006 @default.
• W2023646680 hasConceptScore W2023646680C33923547 @default.
• W2023646680 hasConceptScore W2023646680C34862557 @default.
• W2023646680 hasConceptScore W2023646680C41008148 @default.
• W2023646680 hasConceptScore W2023646680C60644358 @default.
• W2023646680 hasConceptScore W2023646680C76155785 @default.
• W2023646680 hasConceptScore W2023646680C86803240 @default.
• W2023646680 hasConceptScore W2023646680C98045186 @default.
• W2023646680 hasIssue "11" @default.
• W2023646680 hasLocation W20236466801 @default.
• W2023646680 hasLocation W20236466802 @default.
• W2023646680 hasLocation W20236466803 @default.
• W2023646680 hasLocation W20236466804 @default.
• W2023646680 hasOpenAccess W2023646680 @default.
• W2023646680 hasPrimaryLocation W20236466801 @default.
• W2023646680 hasRelatedWork W2023646680 @default.
• W2023646680 hasRelatedWork W2033524626 @default.

• next