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- W2023647117 abstract "Transgenic mice expressing a T cell receptor heterodimer specific for a fragment of pigeon cytochrome c plus an MHC class II molecule (I-Ek) have been made. We find that H-2k αβ transgenic mice have an overall increase in the number of T cells and express a 10-fold higher fraction of cytochrome c-reactive cells than H-2b mice. Surface staining of thymocytes indicates that in H-2b mice, T cell development is arrested at an intermediate stage of differentiation (CD4+8+, CD3lo). Analyses of mice carrying these T cell receptor genes and MHC class II I-Eα constructs indicate that this developmental block can be reversed in H-2b mice by I-E expression on cortical epithelial cells of the thymus. These data suggest that a direct T cell receptor-MHC interaction occurs in the thymus in the absence of nominal antigen and results in the enhanced export of T cells, consistent with the concept of “positive selection.”" @default.
- W2023647117 created "2016-06-24" @default.
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- W2023647117 date "1989-09-22" @default.
- W2023647117 modified "2023-10-11" @default.
- W2023647117 title "Antigen/MHC-specific T cells are preferentially exported from the thymus in the presence of their MHC ligand" @default.
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- W2023647117 cites W1684880136 @default.
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- W2023647117 cites W1832245834 @default.
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- W2023647117 doi "https://doi.org/10.1016/0092-8674(89)90502-3" @default.
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