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- W2023649986 abstract "A multiple-dose double radioiron technic was used to compare absorption of iron administered as a controlled-release (CR) capsule and as an elixir; both formulations contained 50 mg elemental iron as ferrous sulfate. When taken by normal subjects in the fasting state, mean absorption from the elixir and CR capsule averaged 4.92% and 4.38%, which gave a CR capsule: elixir ratio of 0.89. This difference was not significant, but when taken with meals that inhibit absorption of dietary iron by different degrees, absorption of the CR formulation was superior. CR capsule: elixir absorption ratios averaged 1.70 from a meal that is mildly inhibitory and 3.13 from a meal that causes more marked inhibition. It is concluded that CR iron formulations may offer a therapeutic advantage to patients who take oral iron with meals to avoid gastrointestinal side effects. Clinical Pharmacology and Therapeutics (1982) 32, 531–539; doi:10.1038/clpt.1982.198" @default.
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- W2023649986 date "1982-10-01" @default.
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- W2023649986 title "Absorption of controlled-release iron" @default.
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- W2023649986 doi "https://doi.org/10.1038/clpt.1982.198" @default.
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