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• W2023650122 abstract "A glucose biosensor based on an amperometric oxygen electrode has been developed. The properties of oxygen-permeable membranes by dip-coating the oxygen electrode in silastic materials have been compared with those using a standard PTFE mechanically attached membrane. Glucose diffusion membranes of different thicknesses also made from silastic layers have been studied in order to optimize the sensor parameters: response time, sensitivity and the concentration range of linear response. The sensor utilizing silicon water-based elastomer (Dow Corning 3-5025) for preparation of both oxygen and glucose membranes demonstrates a linearity up to 330 mg/dl glucose and a response time of about 10 min. The enzyme in the sensor, glucose oxidase, can be replaced (the sensor refilled) without surgical removal of the sensor form the patient. Refilling of the sensor is achieved by injecting fresh immobilized enzyme into the sensor using a septum. A special technique for immobilization of the enzyme on ultra-low-temperature isotropic (ULTI) carbon powder held in a liquid suspension has been developed Preliminary studies of the sensors for long-term stability, carried out as a continuous operational test in 100 mg/dl glucose, show practically constant sensitivity of the sensor (an average value of 0.0548±0.0049 μA per 100 mg/dl) over two months of continous operation. During this period the sensor was refilled three times." @default.
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• W2023650122 date "1994-01-01" @default.
• W2023650122 modified "2023-10-02" @default.
• W2023650122 title "Towards an implantable and refillable glucose sensor based on oxygen electrode principles" @default.
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• W2023650122 doi "https://doi.org/10.1016/0925-4005(94)87041-1" @default.
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