Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023651057> ?p ?o ?g. }
- W2023651057 endingPage "849" @default.
- W2023651057 startingPage "837" @default.
- W2023651057 abstract "M protein mutant vesicular stomatitis virus is an attractive candidate oncolytic virus for the treatment of metastatic colorectal cancer due to its ability to kill cancer cells that are defective in their antiviral responses. The oncolytic activity of recombinant wild-type and M protein mutant vesicular stomatitis viruses was determined in RKO, Hct116 and LoVo colorectal cancer cells, as well as in human fibroblast and hepatocyte primary cultures. RKO and Hct116 cells were sensitive to both viruses, whereas LoVo cells were resistant. [35S]methionine labeling experiments and viral plaque assays showed that sensitive and resistant colorectal cancer cells supported viral protein and progeny production after infection with either virus. Colorectal cancer cells were pretreated with β-interferon and infected with vesicular stomatitis virus to evaluate the extent to which interferon signaling is downregulated in colorectal cancer cells. Although colorectal cancer cells retained some degree of interferon signaling, this signaling did not negatively impact the oncolytic effects of either virus in sensitive cells. Murine xenografts of RKO cells were effectively treated by intratumoral injections with M protein mutant virus, whereas LoVo xenografts were resistant to treatment with this virus. These results suggest that M protein mutant vesicular stomatitis virus is a good candidate oncolytic virus for the treatment of selected metastatic colorectal cancers." @default.
- W2023651057 created "2016-06-24" @default.
- W2023651057 creator A5011679584 @default.
- W2023651057 creator A5035248018 @default.
- W2023651057 creator A5042758683 @default.
- W2023651057 creator A5061797793 @default.
- W2023651057 creator A5085840629 @default.
- W2023651057 date "2011-09-02" @default.
- W2023651057 modified "2023-10-07" @default.
- W2023651057 title "Vesicular stomatitis virus as a treatment for colorectal cancer" @default.
- W2023651057 cites W1542691850 @default.
- W2023651057 cites W1969390441 @default.
- W2023651057 cites W1970060539 @default.
- W2023651057 cites W1973041539 @default.
- W2023651057 cites W1974681384 @default.
- W2023651057 cites W1977544564 @default.
- W2023651057 cites W1987069333 @default.
- W2023651057 cites W1988365044 @default.
- W2023651057 cites W1990565001 @default.
- W2023651057 cites W2008620560 @default.
- W2023651057 cites W2029231905 @default.
- W2023651057 cites W2039288747 @default.
- W2023651057 cites W2043192660 @default.
- W2023651057 cites W2052758181 @default.
- W2023651057 cites W2053569853 @default.
- W2023651057 cites W2058025467 @default.
- W2023651057 cites W2064739631 @default.
- W2023651057 cites W2082498054 @default.
- W2023651057 cites W2092352693 @default.
- W2023651057 cites W2095537460 @default.
- W2023651057 cites W2096602182 @default.
- W2023651057 cites W2098867430 @default.
- W2023651057 cites W2100025280 @default.
- W2023651057 cites W2101995865 @default.
- W2023651057 cites W2106627189 @default.
- W2023651057 cites W2113562534 @default.
- W2023651057 cites W2115983165 @default.
- W2023651057 cites W2123856999 @default.
- W2023651057 cites W2124160523 @default.
- W2023651057 cites W2127954678 @default.
- W2023651057 cites W2131132108 @default.
- W2023651057 cites W2139610077 @default.
- W2023651057 cites W2150636189 @default.
- W2023651057 cites W2150701651 @default.
- W2023651057 cites W2154530515 @default.
- W2023651057 cites W2156602142 @default.
- W2023651057 cites W2160002698 @default.
- W2023651057 cites W2169101810 @default.
- W2023651057 doi "https://doi.org/10.1038/cgt.2011.49" @default.
- W2023651057 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3682425" @default.
- W2023651057 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21886191" @default.
- W2023651057 hasPublicationYear "2011" @default.
- W2023651057 type Work @default.
- W2023651057 sameAs 2023651057 @default.
- W2023651057 citedByCount "23" @default.
- W2023651057 countsByYear W20236510572012 @default.
- W2023651057 countsByYear W20236510572013 @default.
- W2023651057 countsByYear W20236510572014 @default.
- W2023651057 countsByYear W20236510572015 @default.
- W2023651057 countsByYear W20236510572016 @default.
- W2023651057 countsByYear W20236510572018 @default.
- W2023651057 countsByYear W20236510572019 @default.
- W2023651057 countsByYear W20236510572020 @default.
- W2023651057 countsByYear W20236510572021 @default.
- W2023651057 countsByYear W20236510572023 @default.
- W2023651057 crossrefType "journal-article" @default.
- W2023651057 hasAuthorship W2023651057A5011679584 @default.
- W2023651057 hasAuthorship W2023651057A5035248018 @default.
- W2023651057 hasAuthorship W2023651057A5042758683 @default.
- W2023651057 hasAuthorship W2023651057A5061797793 @default.
- W2023651057 hasAuthorship W2023651057A5085840629 @default.
- W2023651057 hasBestOaLocation W20236510571 @default.
- W2023651057 hasConcept C121608353 @default.
- W2023651057 hasConcept C159047783 @default.
- W2023651057 hasConcept C2522874641 @default.
- W2023651057 hasConcept C2776178377 @default.
- W2023651057 hasConcept C2779057330 @default.
- W2023651057 hasConcept C502942594 @default.
- W2023651057 hasConcept C526805850 @default.
- W2023651057 hasConcept C54355233 @default.
- W2023651057 hasConcept C82210918 @default.
- W2023651057 hasConcept C86803240 @default.
- W2023651057 hasConceptScore W2023651057C121608353 @default.
- W2023651057 hasConceptScore W2023651057C159047783 @default.
- W2023651057 hasConceptScore W2023651057C2522874641 @default.
- W2023651057 hasConceptScore W2023651057C2776178377 @default.
- W2023651057 hasConceptScore W2023651057C2779057330 @default.
- W2023651057 hasConceptScore W2023651057C502942594 @default.
- W2023651057 hasConceptScore W2023651057C526805850 @default.
- W2023651057 hasConceptScore W2023651057C54355233 @default.
- W2023651057 hasConceptScore W2023651057C82210918 @default.
- W2023651057 hasConceptScore W2023651057C86803240 @default.
- W2023651057 hasIssue "12" @default.
- W2023651057 hasLocation W20236510571 @default.
- W2023651057 hasLocation W20236510572 @default.
- W2023651057 hasLocation W20236510573 @default.
- W2023651057 hasLocation W20236510574 @default.
- W2023651057 hasOpenAccess W2023651057 @default.