FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023651235> ?p ?o ?g. }

• W2023651235 endingPage "932" @default.
• W2023651235 startingPage "925" @default.
• W2023651235 abstract "1 In a physiological salt solution (PSS) in which potassium (K) was replaced by rubidium (Rb), segments of rat aorta precontracted with 20 mm RbCl were fully relaxed by K-channel openers with an order of potency levcromakalim > cromakalim > aprikalim > RP 49356. These relaxations were inhibited by glibenclamide. 2 Segments of rat aorta bathed in normal PSS and precontracted with 20 mm KCl were also relaxed by these K-channel openers with an order of potency levcromakalim > cromakalim > aprikalim > RP 49356. These relaxations were glibenclamide-sensitive. However, the absolute potencies of the K-channel openers were approximately four times greater in normal PSS than in RbPSS. 3 In RbPSS, minoxidil sulphate relaxed segments of aorta precontracted with 20 mm RbCl by approximately 20% whereas in normal PSS it fully relaxed those contracted with 20 mm KCl. 4 In RbPSS, levcromakalim-induced relaxation of aortic segments precontracted with 20 mm RbCl was initially well-maintained but then faded by approximately 60% of the initial relaxation to a new, stable level. Subsequent exposure to RP 49356 or to higher concentrations of levcromakalim was without further relaxant effect. Similar changes were observed when RP 49356 was the initial relaxant and tissues were exposed to either RP 49356 or levcromakalim. In normal PSS, levcromakalim- or RP 49356-induced relaxation of contractions produced by 20 mm KCl was well-maintained. 5 In RbPSS, minoxidil sulphate-induced relaxation of aortic segments precontracted with 20 mm RbCl was well-maintained. Subsequent exposure to either levcromakalim or to RP 49356 produced further tissue relaxation. 6 In RbPSS, levcromakalim produced no detectable increase in either 86Rb- or 42K-efflux from rat aortic strips. In normal PSS, a significant increase in the exchange of both isotopes was detected. 7 Levcromakalim hyperpolarized segments of rat aorta bathed both in normal PSS and after depolarization by the addition of 20 mm KCl. Exposure to RbPSS depolarized the tissue and under these conditions, levcromakalim had no effect on membrane potential. 8 In Rb- and normal PSS, levcromakalim produced a similar degree of inhibition of the refilling of the noradrenaline-sensitive Ca store. 9 It is concluded that millimolar concentrations of Rb inhibit the plasmalemmal ATP-sensitive K-channels (KAtp) which are the target of the K-channel openers. The relaxant actions of the K-channel openers in both normal and Rb-PSS and the inhibition of these effects by glibenclamide may reflect a functional interaction between these agents at ATP-binding sites associated with both KATP and with intracellular structures including Ca stores." @default.
• W2023651235 created "2016-06-24" @default.
• W2023651235 creator A5078907845 @default.
• W2023651235 creator A5083787772 @default.
• W2023651235 date "1993-08-01" @default.
• W2023651235 modified "2023-10-14" @default.
• W2023651235 title "Effects of rubidium on responses to potassium channel openers in rat isolated aorta" @default.
• W2023651235 cites W1927242987 @default.
• W2023651235 cites W1971553961 @default.
• W2023651235 cites W1975909527 @default.
• W2023651235 cites W1983680020 @default.
• W2023651235 cites W1986047851 @default.
• W2023651235 cites W1986558776 @default.
• W2023651235 cites W1989438601 @default.
• W2023651235 cites W1989723929 @default.
• W2023651235 cites W2003012370 @default.
• W2023651235 cites W2011575410 @default.
• W2023651235 cites W2011682123 @default.
• W2023651235 cites W2033465778 @default.
• W2023651235 cites W2036670583 @default.
• W2023651235 cites W2044151174 @default.
• W2023651235 cites W2047306983 @default.
• W2023651235 cites W2047353921 @default.
• W2023651235 cites W2050738091 @default.
• W2023651235 cites W2052001060 @default.
• W2023651235 cites W2053130739 @default.
• W2023651235 cites W2054046109 @default.
• W2023651235 cites W2081682110 @default.
• W2023651235 cites W2116963442 @default.
• W2023651235 cites W2156020778 @default.
• W2023651235 cites W2161540449 @default.
• W2023651235 cites W2170976907 @default.
• W2023651235 cites W2429891279 @default.
• W2023651235 cites W43628503 @default.
• W2023651235 doi "https://doi.org/10.1111/j.1476-5381.1993.tb13709.x" @default.
• W2023651235 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2175758" @default.
• W2023651235 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8401946" @default.
• W2023651235 hasPublicationYear "1993" @default.
• W2023651235 type Work @default.
• W2023651235 sameAs 2023651235 @default.
• W2023651235 citedByCount "31" @default.
• W2023651235 countsByYear W20236512352014 @default.
• W2023651235 countsByYear W20236512352020 @default.
• W2023651235 countsByYear W20236512352023 @default.
• W2023651235 crossrefType "journal-article" @default.
• W2023651235 hasAuthorship W2023651235A5078907845 @default.
• W2023651235 hasAuthorship W2023651235A5083787772 @default.
• W2023651235 hasBestOaLocation W20236512351 @default.
• W2023651235 hasConcept C126322002 @default.
• W2023651235 hasConcept C134018914 @default.
• W2023651235 hasConcept C178790620 @default.
• W2023651235 hasConcept C185592680 @default.
• W2023651235 hasConcept C202751555 @default.
• W2023651235 hasConcept C2777194220 @default.
• W2023651235 hasConcept C2779711729 @default.
• W2023651235 hasConcept C2779768347 @default.
• W2023651235 hasConcept C2779980429 @default.
• W2023651235 hasConcept C2780561956 @default.
• W2023651235 hasConcept C517785266 @default.
• W2023651235 hasConcept C55493867 @default.
• W2023651235 hasConcept C555293320 @default.
• W2023651235 hasConcept C57992300 @default.
• W2023651235 hasConcept C71924100 @default.
• W2023651235 hasConcept C83743174 @default.
• W2023651235 hasConceptScore W2023651235C126322002 @default.
• W2023651235 hasConceptScore W2023651235C134018914 @default.
• W2023651235 hasConceptScore W2023651235C178790620 @default.
• W2023651235 hasConceptScore W2023651235C185592680 @default.
• W2023651235 hasConceptScore W2023651235C202751555 @default.
• W2023651235 hasConceptScore W2023651235C2777194220 @default.
• W2023651235 hasConceptScore W2023651235C2779711729 @default.
• W2023651235 hasConceptScore W2023651235C2779768347 @default.
• W2023651235 hasConceptScore W2023651235C2779980429 @default.
• W2023651235 hasConceptScore W2023651235C2780561956 @default.
• W2023651235 hasConceptScore W2023651235C517785266 @default.
• W2023651235 hasConceptScore W2023651235C55493867 @default.
• W2023651235 hasConceptScore W2023651235C555293320 @default.
• W2023651235 hasConceptScore W2023651235C57992300 @default.
• W2023651235 hasConceptScore W2023651235C71924100 @default.
• W2023651235 hasConceptScore W2023651235C83743174 @default.
• W2023651235 hasIssue "4" @default.
• W2023651235 hasLocation W20236512351 @default.
• W2023651235 hasLocation W20236512352 @default.
• W2023651235 hasLocation W20236512353 @default.
• W2023651235 hasLocation W20236512354 @default.
• W2023651235 hasOpenAccess W2023651235 @default.
• W2023651235 hasPrimaryLocation W20236512351 @default.
• W2023651235 hasRelatedWork W1984220439 @default.
• W2023651235 hasRelatedWork W2023651235 @default.
• W2023651235 hasRelatedWork W2025342272 @default.
• W2023651235 hasRelatedWork W2058847275 @default.
• W2023651235 hasRelatedWork W2061137068 @default.
• W2023651235 hasRelatedWork W2076828454 @default.
• W2023651235 hasRelatedWork W2118794191 @default.
• W2023651235 hasRelatedWork W2160068626 @default.
• W2023651235 hasRelatedWork W2160452130 @default.
• W2023651235 hasRelatedWork W4232713311 @default.
• W2023651235 hasVolume "109" @default.

• next