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- W2023651711 abstract "Prostaglandin PGF2α was immobilized onto a poly(vinyl alcohol) hydrogel (PVA) by reaction of a PGF2α-polylysine adduct with glutaraldehyde. The PGF2α-polylysine adduct was prepared by carbodiimide activation of the carboxyl group of PGF2α followed by coupling to the lysine. The adduct was separated from the unreacted PGF2α by dialysis and the purified product was found to contain ∼-44 mol of PGF2α/mol of adduct involving ∼-40% of the amines of the polylysine. The adduct was bound to PVA by reacting with an excess of glutaraldehyde at 0°C, followed by cross-linking of the PVA to a gel at 35–37°C. The PGF2α of the adduct was found to retain ∼-40% of its biological activity on a molar basis in a smooth muscle cell contraction assay, but its activity immobilized to PVA was not determined. Spectroscopically, infrared nuclear magnetic resonance (IR/NMR), the PGF2α appeared identical to the native molecule, except for the amide bond at its carboxylic acid, suggesting that the reactions were very gentle and that other biomolecules could be incorporated into the gel without loss of activity." @default.
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- W2023651711 date "1988-09-01" @default.
- W2023651711 modified "2023-09-26" @default.
- W2023651711 title "Immobilization of prostaglandin PGF2α on poly (vinyl alcohol)" @default.
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- W2023651711 doi "https://doi.org/10.1016/0142-9612(88)90008-7" @default.
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