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• W2023652114 abstract "There have been few reports on the effects of the brain-gut peptide motilin on the central nervous system (CNS). We administered motilin intracerebroventricularly to mice and investigated the effect of motilin on anxiety using an elevated plus-maze. Motilin produced a significant decrease in anxiety with an inverted U-shaped dose response. To determine whether the anxiolytic effect of motilin was mediated via motilin receptors in the brain, the effect of GM-109, a novel motilin receptor antagonist, was investigated. GM-109 showed a significant and dose-dependent antagonism on the motilin-induced anxiolytic effect. GM-109 administered alone had no effect on anxiety. These results suggest that motilin receptors are present in the brain and may have a role in anxiety and emotion." @default.
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• W2023652114 date "1998-01-01" @default.
• W2023652114 modified "2023-10-16" @default.
• W2023652114 title "Anxiolytic effect of motilin and reversal with GM-109, a motilin antagonist, in mice" @default.
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• W2023652114 doi "https://doi.org/10.1016/s0196-9781(98)00131-4" @default.
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