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- W2023652395 abstract "Although large conductance Ca2+-activated K+ (BK) channels play an important role in determining vascular tone, their role in the efferent cardiac vagal system remains to be elucidated. In anesthetized rabbits (n=9), acetylcholine (ACh) was measured at the right atrium near the sinoatrial node by a cardiac microdialysis technique, and the ACh release in response to electrical stimulation of the cervical preganglionic vagal nerves was examined. Local administration of a BK channel blocker iberiotoxin (2 μM) through a dialysis fiber increased the stimulation-induced ACh release from 7.6±2.7 to 9.0±3.2 nM (P<0.05). Addition of intravenous administration of iberiotoxin (0.11 mg/body) did not increase the stimulation-induced ACh release further (10.8±4.4 nM). These results indicate that the BK channels play an inhibitory role in the vagal ACh release to the sinoatrial node." @default.
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- W2023652395 date "2010-08-01" @default.
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- W2023652395 title "Large conductance Ca2+-activated K+ channels inhibit vagal acetylcholine release at the rabbit sinoatrial node" @default.
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- W2023652395 doi "https://doi.org/10.1016/j.autneu.2010.04.003" @default.
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