FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023653390> ?p ?o ?g. }

• W2023653390 endingPage "1480" @default.
• W2023653390 startingPage "1471" @default.
• W2023653390 abstract "Abstract Artemisinins are a class of compounds that are first‐line treatment options for malaria. They also have potent antiproliferative activity, which makes them potential anticancer drugs. We have previously demonstrated anticancer activity of a number of these compounds in vitro ; however, cytotoxic activities were compromised by drug‐induced cell cycle arrests. In this study, we have explored further the activity of the clinical lead artemisinin‐drug artesunate (ART), used either alone or in combination with established chemotherapy. Also, by using a cell line expressing polyploidy character, have also explored the impact of cell cycle arrest in determining overall drug activity. Results showed that ART caused dose‐dependent decreases in cell number, which were associated with either increased cytotoxicity or cytostasis. Cytostasis appeared to be a consequence of a simultaneous arrest at all phases of the cell cycle, a deduction that was supported by molecular profiling, which showed reductions in cell cycle transit proteins. ART appeared to maintain cells in this arrested state; however, reculturing these treated cells in drug‐free medium resulted in significant reductions in viabilities. We also showed that ART maintained activity in polyploidy cells, and that an impressive enhancement to its activity was achievable through a combination with the immunomodulatory drug lenalidomide. Taken together, these observations indicate ART and its related compounds may be effective for the treatment of tumours, and that activity is related to schedule. Therefore, it is important to carefully select the most appropriate schedule to maximise ART efficacy." @default.
• W2023653390 created "2016-06-24" @default.
• W2023653390 creator A5024360706 @default.
• W2023653390 creator A5067606220 @default.
• W2023653390 creator A5084704915 @default.
• W2023653390 date "2010-11-28" @default.
• W2023653390 modified "2023-10-18" @default.
• W2023653390 title "The antimalarial agent artesunate possesses anticancer properties that can be enhanced by combination strategies" @default.
• W2023653390 cites W132685411 @default.
• W2023653390 cites W1963728755 @default.
• W2023653390 cites W1965410016 @default.
• W2023653390 cites W1966091165 @default.
• W2023653390 cites W1967596683 @default.
• W2023653390 cites W1971251266 @default.
• W2023653390 cites W1973840375 @default.
• W2023653390 cites W1989376770 @default.
• W2023653390 cites W1993494844 @default.
• W2023653390 cites W1995044697 @default.
• W2023653390 cites W2000526989 @default.
• W2023653390 cites W2002222120 @default.
• W2023653390 cites W2014387796 @default.
• W2023653390 cites W2015301828 @default.
• W2023653390 cites W2032415936 @default.
• W2023653390 cites W2035228001 @default.
• W2023653390 cites W2036712984 @default.
• W2023653390 cites W2038403656 @default.
• W2023653390 cites W2040450077 @default.
• W2023653390 cites W2041414354 @default.
• W2023653390 cites W2045802318 @default.
• W2023653390 cites W2051905139 @default.
• W2023653390 cites W2063885326 @default.
• W2023653390 cites W2078500738 @default.
• W2023653390 cites W2087976729 @default.
• W2023653390 cites W2088694924 @default.
• W2023653390 cites W2090422859 @default.
• W2023653390 cites W2090875588 @default.
• W2023653390 cites W2098543283 @default.
• W2023653390 cites W2100779485 @default.
• W2023653390 cites W2115103304 @default.
• W2023653390 cites W2120796946 @default.
• W2023653390 cites W2133082107 @default.
• W2023653390 cites W2143010136 @default.
• W2023653390 cites W2152785619 @default.
• W2023653390 doi "https://doi.org/10.1002/ijc.25707" @default.
• W2023653390 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20886599" @default.
• W2023653390 hasPublicationYear "2010" @default.
• W2023653390 type Work @default.
• W2023653390 sameAs 2023653390 @default.
• W2023653390 citedByCount "61" @default.
• W2023653390 countsByYear W20236533902012 @default.
• W2023653390 countsByYear W20236533902013 @default.
• W2023653390 countsByYear W20236533902014 @default.
• W2023653390 countsByYear W20236533902015 @default.
• W2023653390 countsByYear W20236533902016 @default.
• W2023653390 countsByYear W20236533902017 @default.
• W2023653390 countsByYear W20236533902018 @default.
• W2023653390 countsByYear W20236533902019 @default.
• W2023653390 countsByYear W20236533902020 @default.
• W2023653390 countsByYear W20236533902021 @default.
• W2023653390 countsByYear W20236533902022 @default.
• W2023653390 countsByYear W20236533902023 @default.
• W2023653390 crossrefType "journal-article" @default.
• W2023653390 hasAuthorship W2023653390A5024360706 @default.
• W2023653390 hasAuthorship W2023653390A5067606220 @default.
• W2023653390 hasAuthorship W2023653390A5084704915 @default.
• W2023653390 hasBestOaLocation W20236533901 @default.
• W2023653390 hasConcept C109316439 @default.
• W2023653390 hasConcept C126322002 @default.
• W2023653390 hasConcept C1491633281 @default.
• W2023653390 hasConcept C182547069 @default.
• W2023653390 hasConcept C185592680 @default.
• W2023653390 hasConcept C202751555 @default.
• W2023653390 hasConcept C203014093 @default.
• W2023653390 hasConcept C2776120307 @default.
• W2023653390 hasConcept C2776694085 @default.
• W2023653390 hasConcept C2776999253 @default.
• W2023653390 hasConcept C2777292972 @default.
• W2023653390 hasConcept C2778048844 @default.
• W2023653390 hasConcept C2778059366 @default.
• W2023653390 hasConcept C2778371730 @default.
• W2023653390 hasConcept C2780035454 @default.
• W2023653390 hasConcept C29537977 @default.
• W2023653390 hasConcept C55493867 @default.
• W2023653390 hasConcept C71924100 @default.
• W2023653390 hasConcept C98274493 @default.
• W2023653390 hasConceptScore W2023653390C109316439 @default.
• W2023653390 hasConceptScore W2023653390C126322002 @default.
• W2023653390 hasConceptScore W2023653390C1491633281 @default.
• W2023653390 hasConceptScore W2023653390C182547069 @default.
• W2023653390 hasConceptScore W2023653390C185592680 @default.
• W2023653390 hasConceptScore W2023653390C202751555 @default.
• W2023653390 hasConceptScore W2023653390C203014093 @default.
• W2023653390 hasConceptScore W2023653390C2776120307 @default.
• W2023653390 hasConceptScore W2023653390C2776694085 @default.
• W2023653390 hasConceptScore W2023653390C2776999253 @default.
• W2023653390 hasConceptScore W2023653390C2777292972 @default.
• W2023653390 hasConceptScore W2023653390C2778048844 @default.
• W2023653390 hasConceptScore W2023653390C2778059366 @default.

• next