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• W2023653919 abstract "We have previously found that brief infusion (2 minutes) of a placental extract into the carotid artery inhibited spontaneous fetal breathing in sheep; in 50% of the infusions, the electrocortical activity (ECoG) switched from low voltage (LV) to high voltage (HV). The action was primarily found in the 1-10 kD subfraction and was tissue specific. In the present study we determined the effects of a more prolonged infusion of the 1-10 kD subfraction(over 3 hr) to see if the inhibition of breathing was independent of changes in ECoG and whether it persisted throughout the infusion. Infusion of the 1-10 kD subfraction (40 cc/hr) into the carotid artery of the fetal sheep (139± 2 days of gestation), induced a decrease in the incidence of breathing from 58% (baseline) to 43%, 27%, and 7% during the first, second, and third hour of infusion respectively (p<0.001); during the first hr post-infusion, breathing increased to 51%. There was also a decrease in the time spent in LV-ECoG from 57% (baseline) to 50%, 38%, and 18% during the 3 hr of infusion (p<0.005); this increased to 58% during the first hr post-infusion. The decrease in breathing was independent of the changes in ECoG, since there was a simultaneous decrease in breathing during LV-ECoG from 92% (baseline) to 65%, 56%, and to 17% during the infusion (p<0.001); this breathing activity in LV-ECoG recovered to 78% during the first hr post infusion. Krebs solution (control) had no effect on breathing or ECoG. No significant changes were observed in blood gases and pH during the infusions. The findings suggest that a) the inhibitory action of the placental factor is independent of changes in electrocortical activity; and b) continuous infusion of a placental factor is capable of inhibiting fetal breathing for prolonged periods and may be responsible for the inhibition of breathing observed in fetal life. Supported by the Children's Hospital of Winnipeg Research Foundation." @default.
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• W2023653919 date "1997-04-01" @default.
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• W2023653919 title "Effects of a Prolonged Infusion of a Placental Extract on Breathing and Electrocortical Activity in the Fetal Sheep. • 1783" @default.
• W2023653919 doi "https://doi.org/10.1203/00006450-199704001-01802" @default.
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