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• W2023653988 endingPage "385" @default.
• W2023653988 startingPage "373" @default.
• W2023653988 abstract "More than 20 years ago, platelet-derived growth factor (PDGF) was identified and later purified. Through recent years of intense research, a large body of information has been collected on how PDGF transduces its biological effects to responding cells. Two homologous receptors, the PDGF α- and β-receptors, have been identified, which are receptor tyrosine kinases. Binding of PDGF leads to activation of the kinase and autophosphorylation. Particularly in the PDGF β-receptor, a considerable number of autophosphorylation sites have been identified, which allow for physical interaction with signal transduction molecules. The signal transduction molecules are often enzymes, which undergo activity changes in conjunction with binding to the receptor. Other signal transduction molecules function as adaptors, which can couple to subunits equipped with catalytic activity. Through the activity changes of inherent or indirectly coupled catalytic activities, a signal is propagated, which ultimately results in a cellular response. PDGF is known to induce migration, proliferation and differentiation of different cell types. An array of signal transduction molecules has been shown to interact with the PDGF β-receptor; several appear to contribute to the generation of the proliferative response, indicating the existence of parallel pathways for this response, which are utilized by many different growth factor receptors. Migration of cells towards PDGF appears to be more strictly dependent on activation of phosphatidylinositol 3′ kinase. Interestingly, the PDGF α-receptor emits negative signals that inhibit simultaneous positive signals for migration induced by this receptor, or by other receptors, such as the PDGF β-receptor. Virtually nothing is known about signal transduction initiated by PDGF, which generates differentiation responses. Since PDGF appears to play a role in different physiological and pathological processes, it is important to continue delineation of signal transduction pathways initiated through activation of the PDGF receptors." @default.
• W2023653988 created "2016-06-24" @default.
• W2023653988 creator A5003411082 @default.
• W2023653988 date "1996-04-01" @default.
• W2023653988 modified "2023-09-23" @default.
• W2023653988 title "Mechanism of action of platelet-derived growth factor" @default.
• W2023653988 cites W109074058 @default.
• W2023653988 cites W1487009260 @default.
• W2023653988 cites W1507299757 @default.
• W2023653988 cites W1518218790 @default.
• W2023653988 cites W1552052272 @default.
• W2023653988 cites W1566540887 @default.
• W2023653988 cites W1585517331 @default.
• W2023653988 cites W1588573376 @default.
• W2023653988 cites W1611838331 @default.
• W2023653988 cites W1612998887 @default.
• W2023653988 cites W176787308 @default.
• W2023653988 cites W1771590610 @default.
• W2023653988 cites W1781314548 @default.
• W2023653988 cites W1793635963 @default.
• W2023653988 cites W1797407644 @default.
• W2023653988 cites W1836607268 @default.
• W2023653988 cites W1838131144 @default.
• W2023653988 cites W1851295704 @default.
• W2023653988 cites W1854914172 @default.
• W2023653988 cites W1892433039 @default.
• W2023653988 cites W1924198160 @default.
• W2023653988 cites W1964822816 @default.
• W2023653988 cites W1965623117 @default.
• W2023653988 cites W1972678919 @default.
• W2023653988 cites W1973365703 @default.
• W2023653988 cites W1973631902 @default.
• W2023653988 cites W1974967725 @default.
• W2023653988 cites W1975642651 @default.
• W2023653988 cites W1979286083 @default.
• W2023653988 cites W1980166477 @default.
• W2023653988 cites W1981389934 @default.
• W2023653988 cites W1982186905 @default.
• W2023653988 cites W1986758681 @default.
• W2023653988 cites W1993651324 @default.
• W2023653988 cites W1997935194 @default.
• W2023653988 cites W1999824494 @default.
• W2023653988 cites W2004771750 @default.
• W2023653988 cites W2005395047 @default.
• W2023653988 cites W2006612457 @default.
• W2023653988 cites W2007745785 @default.
• W2023653988 cites W2008940139 @default.
• W2023653988 cites W2013062168 @default.
• W2023653988 cites W2020292310 @default.
• W2023653988 cites W2022840517 @default.
• W2023653988 cites W2035140776 @default.
• W2023653988 cites W2038816853 @default.
• W2023653988 cites W2039981641 @default.
• W2023653988 cites W2046733107 @default.
• W2023653988 cites W2046974658 @default.
• W2023653988 cites W2051946942 @default.
• W2023653988 cites W2052799365 @default.
• W2023653988 cites W2057015841 @default.
• W2023653988 cites W2070341388 @default.
• W2023653988 cites W2073146277 @default.
• W2023653988 cites W2085366901 @default.
• W2023653988 cites W2088532612 @default.
• W2023653988 cites W2091659591 @default.
• W2023653988 cites W2110153861 @default.
• W2023653988 cites W2131419480 @default.
• W2023653988 cites W2136390877 @default.
• W2023653988 cites W2150228169 @default.
• W2023653988 cites W2154912685 @default.
• W2023653988 cites W2157189324 @default.
• W2023653988 cites W2164515753 @default.
• W2023653988 cites W2164682544 @default.
• W2023653988 cites W2168427813 @default.
• W2023653988 cites W2170300625 @default.
• W2023653988 cites W2170346765 @default.
• W2023653988 cites W2198367915 @default.
• W2023653988 cites W2249984074 @default.
• W2023653988 cites W326168881 @default.
• W2023653988 cites W4236236434 @default.
• W2023653988 cites W4247752893 @default.
• W2023653988 cites W4255080146 @default.
• W2023653988 cites W67399661 @default.
• W2023653988 doi "https://doi.org/10.1016/1357-2725(95)00156-5" @default.
• W2023653988 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9026349" @default.
• W2023653988 hasPublicationYear "1996" @default.
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