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• W2023654881 abstract "Despite the abundant data concerning the pattern diversity of cell death [1-3], scarce evidence is available in the literature documenting step by step the morphological changes in this phenomenon. We noted spontaneous cell demise of a 3T3 fibroblast in a 35 mm culture dish monitored for 180 min. The cells plated on fibronectin were maintained in DMEM supplemented with 10% BSA, 1x non-essential aminoacids, and 1x penicillin/streptomycin. The earliest morphological changes observed were distortions in cell contour that became spiky (A & B). The neighboring cells were normal in terms of morphology as could be seen in the movie accessible at http://www.jcmm.ro/reviste/07_02/images/3T3/ Later the cell border was less evident suggesting a tendency of cell volume reduction, one of features of apoptosis [1, 4], but the cell membrane seemed to remain attached at the previous points of adherence (C). After the earliest alterations in the cell membrane, a delay of approximately 50 min occurred, until the modification of nuclear morphology; the nucleus suddenly condensed, in 1 min only (compare C & D). Simultaneously cytoplasmic vacuolation, a feature of another distinctive form of cell death [5], appeared evident (D). No dramatic change in the nuclear shape noted in the next minutes, even though the condensation finished 60 min after the alteration of the cell periphery (E). At later experimental time, no other events could be recorded (compare E & F), except movements of cytoplasmic structures disposed around the condensed nucleus (see the movie). The neighboring cells showed no tendency for apoptoticcell clearance, suggesting that either the evolution of programmed cell death failed or the conditions were far away to be as similar as in vivo. The reported event could not be included in any pattern described for cell death." @default.
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• W2023654881 date "2003-04-01" @default.
• W2023654881 modified "2023-09-25" @default.
• W2023654881 title "Cell death in cell culture frame by frame: Spontaneous cell demise of a 3T3 fibroblast" @default.
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• W2023654881 doi "https://doi.org/10.1111/j.1582-4934.2003.tb00219.x" @default.
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