Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023656499> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2023656499 endingPage "426" @default.
- W2023656499 startingPage "417" @default.
- W2023656499 abstract "The mechanism of action of a group of synthetic lymphokine-like molecules, the C8-substituted guanine ribonucleosides, was studied. Among their pleiotropic effects on B cells are the increased expression of surface Ia antigens, induction of polyclonal immunoglobulin secretion, enhancement of thymus-dependent as well as thymus-independent antibody responses, and transmission of T cell-like differentiative signals to B cells. However, relatively little is known about their molecular mechanism of action. In the current article, the interaction of 8-bromoguanosine (8BrGuo), a prototypical C8-substituted guanine ribonucleoside, with cellular components was examined. Rapidly exchangeable (free) and slowly exchangeable (bound) 8BrGuo pools exist within B cells. The bound nucleoside pool loses its ability to be retained by a boronate affinity resin (despite its resistance to metabolic processing) and localizes to the cytosol on sucrose density gradients. Binding affinity, ligand specificity, and cellular specificity of binding all correlate closely with observed functional properties of these molecules. Together, these data suggest that the binding interaction mediates the biologic activities of 8BrGuo, and that the binding site acts as a functional nucleoside receptor." @default.
- W2023656499 created "2016-06-24" @default.
- W2023656499 creator A5011837566 @default.
- W2023656499 creator A5042364041 @default.
- W2023656499 date "1989-10-01" @default.
- W2023656499 modified "2023-09-26" @default.
- W2023656499 title "Ligand binding sites for a synthetic B cell growth and differentiation factor" @default.
- W2023656499 cites W1497257941 @default.
- W2023656499 cites W1538479555 @default.
- W2023656499 cites W1552397933 @default.
- W2023656499 cites W1564818536 @default.
- W2023656499 cites W1572320758 @default.
- W2023656499 cites W1589588413 @default.
- W2023656499 cites W1599749655 @default.
- W2023656499 cites W1606306136 @default.
- W2023656499 cites W1608704265 @default.
- W2023656499 cites W1627876142 @default.
- W2023656499 cites W1941371316 @default.
- W2023656499 cites W1942948652 @default.
- W2023656499 cites W1943603140 @default.
- W2023656499 cites W2028924952 @default.
- W2023656499 cites W2040010053 @default.
- W2023656499 cites W2116889329 @default.
- W2023656499 cites W2171009645 @default.
- W2023656499 cites W4321829298 @default.
- W2023656499 doi "https://doi.org/10.1016/0008-8749(89)90301-8" @default.
- W2023656499 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2790967" @default.
- W2023656499 hasPublicationYear "1989" @default.
- W2023656499 type Work @default.
- W2023656499 sameAs 2023656499 @default.
- W2023656499 citedByCount "7" @default.
- W2023656499 crossrefType "journal-article" @default.
- W2023656499 hasAuthorship W2023656499A5011837566 @default.
- W2023656499 hasAuthorship W2023656499A5042364041 @default.
- W2023656499 hasConcept C104317684 @default.
- W2023656499 hasConcept C107824862 @default.
- W2023656499 hasConcept C116569031 @default.
- W2023656499 hasConcept C153911025 @default.
- W2023656499 hasConcept C159654299 @default.
- W2023656499 hasConcept C170493617 @default.
- W2023656499 hasConcept C202751555 @default.
- W2023656499 hasConcept C203014093 @default.
- W2023656499 hasConcept C2776120743 @default.
- W2023656499 hasConcept C2778301229 @default.
- W2023656499 hasConcept C49382859 @default.
- W2023656499 hasConcept C512185932 @default.
- W2023656499 hasConcept C55493867 @default.
- W2023656499 hasConcept C86803240 @default.
- W2023656499 hasConcept C95444343 @default.
- W2023656499 hasConcept C956191 @default.
- W2023656499 hasConceptScore W2023656499C104317684 @default.
- W2023656499 hasConceptScore W2023656499C107824862 @default.
- W2023656499 hasConceptScore W2023656499C116569031 @default.
- W2023656499 hasConceptScore W2023656499C153911025 @default.
- W2023656499 hasConceptScore W2023656499C159654299 @default.
- W2023656499 hasConceptScore W2023656499C170493617 @default.
- W2023656499 hasConceptScore W2023656499C202751555 @default.
- W2023656499 hasConceptScore W2023656499C203014093 @default.
- W2023656499 hasConceptScore W2023656499C2776120743 @default.
- W2023656499 hasConceptScore W2023656499C2778301229 @default.
- W2023656499 hasConceptScore W2023656499C49382859 @default.
- W2023656499 hasConceptScore W2023656499C512185932 @default.
- W2023656499 hasConceptScore W2023656499C55493867 @default.
- W2023656499 hasConceptScore W2023656499C86803240 @default.
- W2023656499 hasConceptScore W2023656499C95444343 @default.
- W2023656499 hasConceptScore W2023656499C956191 @default.
- W2023656499 hasIssue "2" @default.
- W2023656499 hasLocation W20236564991 @default.
- W2023656499 hasLocation W20236564992 @default.
- W2023656499 hasOpenAccess W2023656499 @default.
- W2023656499 hasPrimaryLocation W20236564991 @default.
- W2023656499 hasRelatedWork W1968369877 @default.
- W2023656499 hasRelatedWork W2068999859 @default.
- W2023656499 hasRelatedWork W2155039967 @default.
- W2023656499 hasRelatedWork W2164895434 @default.
- W2023656499 hasRelatedWork W2360587303 @default.
- W2023656499 hasRelatedWork W2375480979 @default.
- W2023656499 hasRelatedWork W3015866085 @default.
- W2023656499 hasRelatedWork W3029908218 @default.
- W2023656499 hasRelatedWork W3031502370 @default.
- W2023656499 hasRelatedWork W8052553 @default.
- W2023656499 hasVolume "123" @default.
- W2023656499 isParatext "false" @default.
- W2023656499 isRetracted "false" @default.
- W2023656499 magId "2023656499" @default.
- W2023656499 workType "article" @default.