FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023657227> ?p ?o ?g. }

• W2023657227 endingPage "27" @default.
• W2023657227 startingPage "18" @default.
• W2023657227 abstract "The amyloid precursor protein (APP) has been mainly studied in its role in the production of amyloid β peptides (Aβ), because Aβ deposition is a hallmark of Alzheimer's disease. Although several studies suggest APP has physiological functions, it is still controversial. We previously reported that APP increased glial differentiation of neural progenitor cells (NPCs). In the current study, NPCs transplanted into APP23 transgenic mice primarily differentiated into glial cells. In vitro treatment with secreted APP (sAPP) dose-dependently increased glial fibrillary acidic protein (GFAP) immuno-positive cells in NPCs and over expression of APP caused most NPCs to differentiate into GFAP immuno-positive cells. Treatment with sAPP also dose-dependently increased expression levels of GFAP in NT-2/D1 cells along with the generation of Notch intracellular domain (NICD) and expression of Hairy and enhancer of split 1 (Hes1). Treatment with γ-secretase inhibitor suppressed the generation of NICD and reduced Hes1 and GFAP expressions. Treatment with the N-terminal domain of APP (APP 1-205) was enough to induce up regulation of GFAP and Hes1 expressions, and application of 22 C11 antibodies recognizing N-terminal APP suppressed these changes by sAPP. These results indicate APP induces glial differentiation of NPCs through Notch signaling." @default.
• W2023657227 created "2016-06-24" @default.
• W2023657227 creator A5000825540 @default.
• W2023657227 creator A5018833578 @default.
• W2023657227 creator A5038172690 @default.
• W2023657227 creator A5051302366 @default.
• W2023657227 creator A5061679326 @default.
• W2023657227 creator A5074092299 @default.
• W2023657227 date "2011-01-01" @default.
• W2023657227 modified "2023-10-01" @default.
• W2023657227 title "Involvement of notch signaling pathway in amyloid precursor protein induced glial differentiation" @default.
• W2023657227 cites W1599737625 @default.
• W2023657227 cites W1622551182 @default.
• W2023657227 cites W1626267121 @default.
• W2023657227 cites W1660631781 @default.
• W2023657227 cites W1844648396 @default.
• W2023657227 cites W1932612562 @default.
• W2023657227 cites W1933062072 @default.
• W2023657227 cites W1973130935 @default.
• W2023657227 cites W1979750648 @default.
• W2023657227 cites W1988450897 @default.
• W2023657227 cites W1989409794 @default.
• W2023657227 cites W1991315413 @default.
• W2023657227 cites W1995344309 @default.
• W2023657227 cites W2001402754 @default.
• W2023657227 cites W2005320724 @default.
• W2023657227 cites W2005875799 @default.
• W2023657227 cites W2012618391 @default.
• W2023657227 cites W2026405806 @default.
• W2023657227 cites W2028191533 @default.
• W2023657227 cites W2030355018 @default.
• W2023657227 cites W2030864229 @default.
• W2023657227 cites W2041016354 @default.
• W2023657227 cites W2046478450 @default.
• W2023657227 cites W2048160728 @default.
• W2023657227 cites W2048163917 @default.
• W2023657227 cites W2056745213 @default.
• W2023657227 cites W2057713102 @default.
• W2023657227 cites W2059330780 @default.
• W2023657227 cites W2059538696 @default.
• W2023657227 cites W2063694838 @default.
• W2023657227 cites W2077780809 @default.
• W2023657227 cites W2079100663 @default.
• W2023657227 cites W2080783854 @default.
• W2023657227 cites W2091898207 @default.
• W2023657227 cites W2097445408 @default.
• W2023657227 cites W2100343757 @default.
• W2023657227 cites W2104516442 @default.
• W2023657227 cites W2113784071 @default.
• W2023657227 cites W2117058176 @default.
• W2023657227 cites W2120580225 @default.
• W2023657227 cites W2128211642 @default.
• W2023657227 cites W2132884452 @default.
• W2023657227 cites W2136697740 @default.
• W2023657227 cites W2147029696 @default.
• W2023657227 cites W2148017536 @default.
• W2023657227 cites W2157156910 @default.
• W2023657227 cites W2158350918 @default.
• W2023657227 cites W2163643958 @default.
• W2023657227 cites W2168940259 @default.
• W2023657227 cites W2169152986 @default.
• W2023657227 cites W4241250543 @default.
• W2023657227 cites W74077904 @default.
• W2023657227 doi "https://doi.org/10.1016/j.ejphar.2010.09.015" @default.
• W2023657227 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2997918" @default.
• W2023657227 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20883690" @default.
• W2023657227 hasPublicationYear "2011" @default.
• W2023657227 type Work @default.
• W2023657227 sameAs 2023657227 @default.
• W2023657227 citedByCount "28" @default.
• W2023657227 countsByYear W20236572272012 @default.
• W2023657227 countsByYear W20236572272013 @default.
• W2023657227 countsByYear W20236572272014 @default.
• W2023657227 countsByYear W20236572272016 @default.
• W2023657227 countsByYear W20236572272017 @default.
• W2023657227 countsByYear W20236572272018 @default.
• W2023657227 countsByYear W20236572272019 @default.
• W2023657227 countsByYear W20236572272020 @default.
• W2023657227 countsByYear W20236572272021 @default.
• W2023657227 countsByYear W20236572272022 @default.
• W2023657227 countsByYear W20236572272023 @default.
• W2023657227 crossrefType "journal-article" @default.
• W2023657227 hasAuthorship W2023657227A5000825540 @default.
• W2023657227 hasAuthorship W2023657227A5018833578 @default.
• W2023657227 hasAuthorship W2023657227A5038172690 @default.
• W2023657227 hasAuthorship W2023657227A5051302366 @default.
• W2023657227 hasAuthorship W2023657227A5061679326 @default.
• W2023657227 hasAuthorship W2023657227A5074092299 @default.
• W2023657227 hasBestOaLocation W20236572272 @default.
• W2023657227 hasConcept C104317684 @default.
• W2023657227 hasConcept C126322002 @default.
• W2023657227 hasConcept C136834591 @default.
• W2023657227 hasConcept C148738053 @default.
• W2023657227 hasConcept C153911025 @default.
• W2023657227 hasConcept C161879069 @default.
• W2023657227 hasConcept C185592680 @default.
• W2023657227 hasConcept C201750760 @default.
• W2023657227 hasConcept C203014093 @default.

• next