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- W2023657507 endingPage "1840" @default.
- W2023657507 startingPage "1828" @default.
- W2023657507 abstract "The parasite Trypanosoma brucei , the causative agent of sleeping sickness across sub-Saharan Africa, depends on a remarkable U-insertion/deletion RNA editing process in its mitochondrion. A approximately 20 S multi-protein complex, called the editosome, is an essential machinery for editing pre-mRNA molecules encoding the majority of mitochondrial proteins. Editosomes contain a common core of twelve proteins where six OB-fold interaction proteins, called A1–A6, play a crucial role. Here, we report the structure of two single-strand nucleic acid-binding OB-folds from interaction proteins A3 and A6 that surprisingly, form a heterodimer. Crystal growth required the assistance of an anti-A3 nanobody as a crystallization chaperone. Unexpectedly, this anti-A3 nanobody binds to both A3 OB and A6, despite only ∼40% amino acid sequence identity between the OB-folds of A3 and A6. The A3 OB -A6 heterodimer buries 35% more surface area than the A6 homodimer. This is attributed mainly to the presence of a conserved Pro-rich loop in A3 OB . The implications of the A3 OB –A6 heterodimer, and of a dimer of heterodimers observed in the crystals, for the architecture of the editosome are profound, resulting in a proposal of a ‘five OB-fold center’ in the core of the editosome." @default.
- W2023657507 created "2016-06-24" @default.
- W2023657507 creator A5001394494 @default.
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- W2023657507 creator A5043024602 @default.
- W2023657507 creator A5048597642 @default.
- W2023657507 creator A5056154663 @default.
- W2023657507 date "2011-10-27" @default.
- W2023657507 modified "2023-10-10" @default.
- W2023657507 title "Crystal structure of a heterodimer of editosome interaction proteins in complex with two copies of a cross-reacting nanobody" @default.
- W2023657507 cites W10876090 @default.
- W2023657507 cites W1539796472 @default.
- W2023657507 cites W1542411948 @default.
- W2023657507 cites W1766305676 @default.
- W2023657507 cites W1806123628 @default.
- W2023657507 cites W1963542761 @default.
- W2023657507 cites W1968354620 @default.
- W2023657507 cites W1973935400 @default.
- W2023657507 cites W1984710466 @default.
- W2023657507 cites W1985629904 @default.
- W2023657507 cites W1987671305 @default.
- W2023657507 cites W1988503886 @default.
- W2023657507 cites W1988963904 @default.
- W2023657507 cites W1989840530 @default.
- W2023657507 cites W1990262429 @default.
- W2023657507 cites W1991214219 @default.
- W2023657507 cites W1992860677 @default.
- W2023657507 cites W2000627319 @default.
- W2023657507 cites W2008506448 @default.
- W2023657507 cites W2016399152 @default.
- W2023657507 cites W2017713846 @default.
- W2023657507 cites W2029582401 @default.
- W2023657507 cites W2031500190 @default.
- W2023657507 cites W2032133188 @default.
- W2023657507 cites W2035503835 @default.
- W2023657507 cites W2038840577 @default.
- W2023657507 cites W2042446618 @default.
- W2023657507 cites W2051075703 @default.
- W2023657507 cites W2053282834 @default.
- W2023657507 cites W2059885056 @default.
- W2023657507 cites W2064306200 @default.
- W2023657507 cites W2067664740 @default.
- W2023657507 cites W2070211116 @default.
- W2023657507 cites W2074570058 @default.
- W2023657507 cites W2074978170 @default.
- W2023657507 cites W2080571030 @default.
- W2023657507 cites W2082038343 @default.
- W2023657507 cites W2088801759 @default.
- W2023657507 cites W2095553811 @default.
- W2023657507 cites W2098672937 @default.
- W2023657507 cites W2100256576 @default.
- W2023657507 cites W2104258472 @default.
- W2023657507 cites W2109184569 @default.
- W2023657507 cites W2114306163 @default.
- W2023657507 cites W2114344934 @default.
- W2023657507 cites W2115276551 @default.
- W2023657507 cites W2118586303 @default.
- W2023657507 cites W2121692632 @default.
- W2023657507 cites W2121748316 @default.
- W2023657507 cites W2126057369 @default.
- W2023657507 cites W2130653277 @default.
- W2023657507 cites W2131004367 @default.
- W2023657507 cites W2132846647 @default.
- W2023657507 cites W2134329032 @default.
- W2023657507 cites W2135006530 @default.
- W2023657507 cites W2135534435 @default.
- W2023657507 cites W2137955461 @default.
- W2023657507 cites W2138077578 @default.
- W2023657507 cites W2138444917 @default.
- W2023657507 cites W2142395283 @default.
- W2023657507 cites W2143815085 @default.
- W2023657507 cites W2144081223 @default.
- W2023657507 cites W2144269804 @default.
- W2023657507 cites W2145081087 @default.
- W2023657507 cites W2145594096 @default.
- W2023657507 cites W2149038592 @default.
- W2023657507 cites W2150265408 @default.
- W2023657507 cites W2153641622 @default.
- W2023657507 cites W2154518053 @default.
- W2023657507 cites W2154714625 @default.
- W2023657507 cites W2156929173 @default.
- W2023657507 cites W2158616999 @default.
- W2023657507 cites W2159889468 @default.
- W2023657507 cites W2160942775 @default.
- W2023657507 cites W2162244749 @default.
- W2023657507 cites W2163341755 @default.
- W2023657507 cites W2167088076 @default.
- W2023657507 cites W2167358828 @default.
- W2023657507 cites W2168140297 @default.
- W2023657507 cites W2169523472 @default.
- W2023657507 cites W2171145510 @default.
- W2023657507 cites W2171810840 @default.
- W2023657507 cites W2171895257 @default.
- W2023657507 cites W2171910259 @default.
- W2023657507 cites W2178168667 @default.
- W2023657507 cites W2183157368 @default.
- W2023657507 cites W4229957730 @default.
- W2023657507 cites W4232090872 @default.