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• W2023657616 abstract "Examination of annexin V binding, an indicator of early apoptosis, on lymphocytes from HIV+people immediately after isolation showed that both CD4+and CD8+T cells were apoptotic, whereas B cell apoptosis was induced mainly after incubation. CD8+T cell apoptosis correlated with fewer CD4+T cells, but not the level of viremia. To determine potential mechanisms for apoptosis, we examined FasL expression, which was dramatically elevated on CD14+monocytes; however, antibody to FasL did not reproducibly inhibit apoptosis. Rather, CD8+T cell apoptosis was caused by antigen-presenting cells because removal of monocytes or addition of antibodies to CD80 and CD86 reduced apoptosis. B cell apoptosis also involved costimulatory signals delivered by T cells but not monocytes. A unique CD8brightCD28dimT cell population died after costimulation by monocytes. Because this population was increased in patients with undetectable viremia, abnormal antigen-presenting cells may contribute to continued CD8+T cell exhaustion by inducing apoptosis." @default.
• W2023657616 created "2016-06-24" @default.
• W2023657616 creator A5001489839 @default.
• W2023657616 creator A5033900143 @default.
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• W2023657616 date "1999-03-01" @default.
• W2023657616 modified "2023-10-17" @default.
• W2023657616 title "Costimulatory Pathways Mediate Monocyte-Dependent Lymphocyte Apoptosis in HIV" @default.
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• W2023657616 doi "https://doi.org/10.1006/clim.1998.4663" @default.
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