FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2023657624> ?p ?o ?g. }

• W2023657624 endingPage "927" @default.
• W2023657624 startingPage "919" @default.
• W2023657624 abstract "The cardiovascular system is an important target of estrogenic compounds. Considering the recent studies that question previously reported cardio-protective effects of estrogen, there is a growing concern that estrogenic environmental compounds may contribute to the pathology of vascular lesion formation. Real-time quantitative PCR was used to monitor the expression of genes involved in vascularization. Using Bayesian network modeling, we determined a gene network that estrogenic chemicals modulate in human vascular endothelial cells. We showed that planar and coplanar polychlorinated biphenyls (PCBs) induce the expression of different genes compared to estradiol. Non-planar PCB congener 153 induced NOTCH3 which is a new finding as well as CCL2 and IL8 similar to what has been reported by other non-planar PCBs in endothelial cells. Our gene network indicated that experimental treatments signal a network containing TGF-β receptor and NOTCH3; molecules biologically relevant to signaling pulmonary vascular lesions. We report in the present study that exposure of vascular endothelial cells to environmentally relevant concentrations of estrogenic PCBs induce gene networks implicated in the process of inflammation and adhesion. Our data suggest that PCBs can promote vascular lesion formation by activating gene networks involved in endothelial cell adhesion, cell growth, and pro-inflammatory molecules which were different from natural estrogen. Since inflammation and adhesion are a hallmark in the pathology of endothelial cell dysfunction, reconstructing gene networks provide insight into the potential mechanisms that may contribute to the vascular risks associated with estrogenic environmental chemicals." @default.
• W2023657624 created "2016-06-24" @default.
• W2023657624 creator A5014220523 @default.
• W2023657624 creator A5041034837 @default.
• W2023657624 creator A5066095065 @default.
• W2023657624 date "2010-06-01" @default.
• W2023657624 modified "2023-09-27" @default.
• W2023657624 title "Gene expression profile of endothelial cells exposed to estrogenic environmental compounds: Implications to pulmonary vascular lesions" @default.
• W2023657624 cites W142956129 @default.
• W2023657624 cites W1556701994 @default.
• W2023657624 cites W1967368426 @default.
• W2023657624 cites W1971886191 @default.
• W2023657624 cites W1972480439 @default.
• W2023657624 cites W1973141811 @default.
• W2023657624 cites W1982597476 @default.
• W2023657624 cites W1985311184 @default.
• W2023657624 cites W1985918125 @default.
• W2023657624 cites W1990477938 @default.
• W2023657624 cites W1992334729 @default.
• W2023657624 cites W1994194752 @default.
• W2023657624 cites W2001533364 @default.
• W2023657624 cites W2011610137 @default.
• W2023657624 cites W2017604478 @default.
• W2023657624 cites W2021595727 @default.
• W2023657624 cites W2022796928 @default.
• W2023657624 cites W2023068131 @default.
• W2023657624 cites W2045735485 @default.
• W2023657624 cites W2050052243 @default.
• W2023657624 cites W2057458384 @default.
• W2023657624 cites W2073683019 @default.
• W2023657624 cites W2078347353 @default.
• W2023657624 cites W2097193479 @default.
• W2023657624 cites W2103198327 @default.
• W2023657624 cites W2107277218 @default.
• W2023657624 cites W2109730452 @default.
• W2023657624 cites W2125936072 @default.
• W2023657624 cites W2126228011 @default.
• W2023657624 cites W2127235388 @default.
• W2023657624 cites W2128213692 @default.
• W2023657624 cites W2149499233 @default.
• W2023657624 cites W2167379393 @default.
• W2023657624 cites W2169950372 @default.
• W2023657624 cites W4241506761 @default.
• W2023657624 cites W4242554181 @default.
• W2023657624 cites W4245350504 @default.
• W2023657624 doi "https://doi.org/10.1016/j.lfs.2010.04.007" @default.
• W2023657624 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2916066" @default.
• W2023657624 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20416326" @default.
• W2023657624 hasPublicationYear "2010" @default.
• W2023657624 type Work @default.
• W2023657624 sameAs 2023657624 @default.
• W2023657624 citedByCount "14" @default.
• W2023657624 countsByYear W20236576242012 @default.
• W2023657624 countsByYear W20236576242013 @default.
• W2023657624 countsByYear W20236576242014 @default.
• W2023657624 countsByYear W20236576242015 @default.
• W2023657624 countsByYear W20236576242016 @default.
• W2023657624 countsByYear W20236576242017 @default.
• W2023657624 countsByYear W20236576242018 @default.
• W2023657624 countsByYear W20236576242020 @default.
• W2023657624 countsByYear W20236576242023 @default.
• W2023657624 crossrefType "journal-article" @default.
• W2023657624 hasAuthorship W2023657624A5014220523 @default.
• W2023657624 hasAuthorship W2023657624A5041034837 @default.
• W2023657624 hasAuthorship W2023657624A5066095065 @default.
• W2023657624 hasBestOaLocation W20236576242 @default.
• W2023657624 hasConcept C104317684 @default.
• W2023657624 hasConcept C121608353 @default.
• W2023657624 hasConcept C123012128 @default.
• W2023657624 hasConcept C134018914 @default.
• W2023657624 hasConcept C1491633281 @default.
• W2023657624 hasConcept C150194340 @default.
• W2023657624 hasConcept C16224149 @default.
• W2023657624 hasConcept C202751555 @default.
• W2023657624 hasConcept C203014093 @default.
• W2023657624 hasConcept C2776914184 @default.
• W2023657624 hasConcept C2777164284 @default.
• W2023657624 hasConcept C530470458 @default.
• W2023657624 hasConcept C54355233 @default.
• W2023657624 hasConcept C55493867 @default.
• W2023657624 hasConcept C62478195 @default.
• W2023657624 hasConcept C84606932 @default.
• W2023657624 hasConcept C85789140 @default.
• W2023657624 hasConcept C86803240 @default.
• W2023657624 hasConcept C95444343 @default.
• W2023657624 hasConceptScore W2023657624C104317684 @default.
• W2023657624 hasConceptScore W2023657624C121608353 @default.
• W2023657624 hasConceptScore W2023657624C123012128 @default.
• W2023657624 hasConceptScore W2023657624C134018914 @default.
• W2023657624 hasConceptScore W2023657624C1491633281 @default.
• W2023657624 hasConceptScore W2023657624C150194340 @default.
• W2023657624 hasConceptScore W2023657624C16224149 @default.
• W2023657624 hasConceptScore W2023657624C202751555 @default.
• W2023657624 hasConceptScore W2023657624C203014093 @default.
• W2023657624 hasConceptScore W2023657624C2776914184 @default.
• W2023657624 hasConceptScore W2023657624C2777164284 @default.
• W2023657624 hasConceptScore W2023657624C530470458 @default.
• W2023657624 hasConceptScore W2023657624C54355233 @default.

• next