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• W2023657810 endingPage "347" @default.
• W2023657810 startingPage "337" @default.
• W2023657810 abstract "Since the largely abused worldwide used of marijuana, there have been many ongoing debates regarding the adverse health effects of marijuana smoking. Marijuana smoking was recently proved to cause pulmonary toxicity by inducing genotoxic effects or generating reactive oxygen species. Because p53, a tumor suppressor gene, has an important pathophysiologic role in the regulation of lung epithelial cell DNA damage responses, we hypothesized that p53 may be involved in the oxidative stress-mediated apoptosis induced by marijuana smoking. First, we confirmed that marijuana smoke condensate (MSC) induces oxidative stress in BEAS-2B cells. We observed that reactive oxygen species (ROS) generation was increased by MSC in the DCFH-DA assay. Also, antioxidant enzyme (superoxide dismutase, catalase) activity and their mRNA expressions were up-regulated by MSC. Second, we investigated p53 involvement in the MSC-induced apoptotic pathway in BEAS-2B cells. The results showed that MSC increased caspase-3 activation and DNA fragmentation as markers of apoptosis. In addition, the mRNA levels of apoptosis-related genes (p53 and Bax) were increased by MSC and phospho-p53, along with the increase of Bax protein expression by MSC. Apoptosis and apoptosis-related gene expression were partially blocked by an inhibitor of p53-dependent transcriptional activation (pifithrin-α). The results indicate that p53 plays a role in MSC-induced apoptosis. Taken together, the findings of the present study suggest that MSC partially induces p53-mediated apoptosis through ROS generation in human lung epithelial cells and this may have broader implications for our understanding of pulmonary diseases." @default.
• W2023657810 created "2016-06-24" @default.
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• W2023657810 creator A5052292133 @default.
• W2023657810 date "2013-01-01" @default.
• W2023657810 modified "2023-09-27" @default.
• W2023657810 title "Marijuana smoke condensate induces p53-mediated apoptosis in human lung epithelial cells" @default.
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• W2023657810 cites W1591053743 @default.
• W2023657810 cites W1641440939 @default.
• W2023657810 cites W1902475533 @default.
• W2023657810 cites W1963357788 @default.
• W2023657810 cites W1963597077 @default.
• W2023657810 cites W1964617786 @default.
• W2023657810 cites W1965877134 @default.
• W2023657810 cites W1969502320 @default.
• W2023657810 cites W1973604686 @default.
• W2023657810 cites W1974880556 @default.
• W2023657810 cites W1978653530 @default.
• W2023657810 cites W1980010223 @default.
• W2023657810 cites W1980380119 @default.
• W2023657810 cites W1981887482 @default.
• W2023657810 cites W1997208169 @default.
• W2023657810 cites W1997388033 @default.
• W2023657810 cites W2003485524 @default.
• W2023657810 cites W2004898039 @default.
• W2023657810 cites W2011630421 @default.
• W2023657810 cites W2011818221 @default.
• W2023657810 cites W2020177224 @default.
• W2023657810 cites W2022356399 @default.
• W2023657810 cites W2026094659 @default.
• W2023657810 cites W2029869071 @default.
• W2023657810 cites W2036753213 @default.
• W2023657810 cites W2036867599 @default.
• W2023657810 cites W2045677098 @default.
• W2023657810 cites W2046848104 @default.
• W2023657810 cites W2053089633 @default.
• W2023657810 cites W2059847314 @default.
• W2023657810 cites W2062887883 @default.
• W2023657810 cites W2065246197 @default.
• W2023657810 cites W2068782912 @default.
• W2023657810 cites W2073758178 @default.
• W2023657810 cites W2074565738 @default.
• W2023657810 cites W2079431443 @default.
• W2023657810 cites W2079847011 @default.
• W2023657810 cites W2085505835 @default.
• W2023657810 cites W2090162036 @default.
• W2023657810 cites W2090990681 @default.
• W2023657810 cites W2092335156 @default.
• W2023657810 cites W2095253590 @default.
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• W2023657810 cites W2109773598 @default.
• W2023657810 cites W2114728052 @default.
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• W2023657810 cites W2122512350 @default.
• W2023657810 cites W2123761467 @default.
• W2023657810 cites W2124928988 @default.
• W2023657810 cites W2125357418 @default.
• W2023657810 cites W2135682490 @default.
• W2023657810 cites W2144472894 @default.
• W2023657810 cites W2146718778 @default.
• W2023657810 cites W2148700883 @default.
• W2023657810 cites W2151632264 @default.
• W2023657810 cites W2153456753 @default.
• W2023657810 cites W2155368714 @default.
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• W2023657810 cites W2236824038 @default.
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• W2023657810 doi "https://doi.org/10.2131/jts.38.337" @default.
• W2023657810 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23665932" @default.
• W2023657810 hasPublicationYear "2013" @default.
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