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• W2023658000 abstract "Abstract: Na+-dependent uptake of L-[3H]proline was measured in a crude synaptosomal preparation from the entire rat hippocampal formation or from isolated hippo-campal regions. Among hippocampal regions, Na+-depen-dent proline uptake was significantly greater in areas CA1 and CA2-CA3-CA4 than in the fascia dentata, whereas there was no marked regional difference in the distribution of Na+-dependent γ-[14C]aminobutyric acid ([14C] GABA) uptake. A bilateral kainic acid lesion, which destroyed most of the CA3 hippocampal pyramidal cells, reduced Na+-de-pendent proline uptake by an average of 41% in area CA1 and 52% in area CA2-CA3-CA4, without affecting the Na+-dependent uptake of GABA. In the fascia dentata, neither proline nor GABA uptake was significantly altered. Kinetic studies suggested that hippocampal synaptosomes take up proline by both a high-affinity (KT=6.7 μM) and a low-affinity (KT= 290 μM) Na+-dependent process, whereas L-[14C]glutamate is taken up predominantly by a high-affinity (KT=6.1 μM) process. A bilateral kainic acid lesion reduced the Vmax of high-affinity proline uptake by an average of 72%, the Vmax of low-affinity proline uptake by 44%, and the Vmax of high affinity glutamate Uptake by 43%, without significantly changing the affinity of the transport carriers for substrate. Ipsilateral-commissural projections of CA3 hippocampal pyramidal cells Appear to possess nearly as great a capacity for taking up proline as for taking up glutamate, a probable transmitter of these pathways. Therefore proline may play an important role in transmission at synapses made by the CA3-derived Schaffer collateral, commissural, and ipsilateral associational fibers." @default.
• W2023658000 created "2016-06-24" @default.
• W2023658000 creator A5013691284 @default.
• W2023658000 date "1987-10-01" @default.
• W2023658000 modified "2023-09-26" @default.
• W2023658000 title "Sodium-Dependent Proline Uptake in the Rat Hippocampal Formation: Association with Ipsilateral-Commissural Projections of CA3 Pyramidal" @default.
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• W2023658000 doi "https://doi.org/10.1111/j.1471-4159.1987.tb10006.x" @default.
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