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- W2023658254 abstract "During the management of a 3 kg term black female infant whose chylothorax was diagnosed at 7 days of age, a total of 450 ml of chyle was removed by repeated thoracentesis before spontaneous healing occured. The total number of lymphocytes removed during 18 days was greater than 109. Monoclonal antibody studies showed 95% of these cells were T-lymphocytes which were functionally immature as evidenced by their non-responsiveness to mitogen-There was no associated peripheral blood lymphopenia. Nevertheless, peripheral T-cells were abnormal as shown by lack of sheep RBC rosette formation and lack of response to mitogens. The thymus which was absent during the 18 days of therapy, reappeared 2 weeks after disappearance of the chylothorax accompanied by normalization of peripheral T-lymphocyte functions. Loss of large volumes of chyle in congenital idiopathic chylothorax can cause transient severe depletion of T-lymphocytes associated with cell mediated immune deficiency as evidenced by a decrease in T-cell forming rosettes with either sheep RBC or lymphoblastoid B cell lines, and functional tests of cellular immunity." @default.
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- W2023658254 date "1985-04-01" @default.
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- W2023658254 title "1423 TRANSIENT CELL MEDIATED IMMUNE DEFICIENCY ACCOMPAYING CONGENITAL ISIOPATHIC CHYLOTHORAX" @default.
- W2023658254 doi "https://doi.org/10.1203/00006450-198504000-01447" @default.
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