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• W2023659941 abstract "1 The effect of drugs on the adenosine 3′:5′-cyclic monophosphate (cyclic AMP) content of desmethylimipramine (DMI)-treated bullfrog paravertebral sympathetic ganglia was studied by radioimmunoassay. The adrenaline-induced hyperpolarization (Adh) in this tissue was recorded by means of the sucrose-gap technique. 2 In the presence of propranolol (1 μm) and DMI (0.5 μm), adrenaline (1 μm) significantly reduced the concentration of cyclic AMP in forskolin-treated ganglia. This effect was prevented by pertussis toxin (5 μg ml−1). 3 The relative potency for drugs which increased ganglionic cyclic AMP content was: 50 μm forskolin ≤ 5 mm fluoride > 2 mm fluoride > 2 mm isobutylmethylxanthine (IBMX) > 5 mm caffeine. In contrast, their relative potency for inhibition of the Adh was: 2 mm IBMX > 5 mm fluoride > 5 mm caffeine > 2 mm fluoride > 50 μm forskolin. The Adh was unaffected by pertussis toxin (5 μg ml−1). 4 Although the Adh was slightly reduced by the extracellular application of 8-bromo (8-Br) cyclic AMP, the majority of the data suggest that the transduction mechanism underlying the Adh is independent of the intracellular cyclic AMP concentration and provide an example of an α2-adrenoceptor-mediated response that occurs independently of inhibition of adenylate cyclase." @default.
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• W2023659941 date "1989-04-01" @default.
• W2023659941 modified "2023-09-27" @default.
• W2023659941 title "Elevation of intracellular cyclic AMP concentration fails to inhibit adrenaline-induced hyperpolarization in amphibian sympathetic neurones" @default.
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• W2023659941 doi "https://doi.org/10.1111/j.1476-5381.1989.tb11883.x" @default.
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