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• W2023661646 abstract "Parameter estimation in biological compartment models by optimization procedures is influenced by several conditions: the kind of mathematical representation of the model, the experimental conditions and the conditions related to the estimation process. In this paper the reliability of parameter estimation in a two compartment model is investigated through computer simulation techniques. In particular, the combined effect is studied of the initial guess in the parameter space and of the mathematical representation of the model. The results show that there are some more favorable situations for the estimation. This analysis can help in proper planning of the experimental and computing conditions in which parameter estimation should be performed." @default.
• W2023661646 created "2016-06-24" @default.
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• W2023661646 date "1977-01-01" @default.
• W2023661646 modified "2023-10-18" @default.
• W2023661646 title "Parameter estimation in a biological two compartmental model— a computer experimental study of the influence of the initial estimate in the parameter space and of the model representation" @default.
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• W2023661646 doi "https://doi.org/10.1016/0025-5564(77)90063-3" @default.
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