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• W2023667108 startingPage "11441" @default.
• W2023667108 abstract "Intercellular adhesion molecule 1 (ICAM-1), a counter-receptor for lymphocyte function-associated antigen 1 on T cells, is critically important to a wide variety of adhesion-dependent leukocyte functions, including antigen presentation and target cell lysis. ICAM-1 expression by hepatocytes is increased in areas of inflammation and necrosis during chronic hepatitis B. Whether induction of ICAM-1 is due to the effect of inflammatory cytokines or involves a direct effect of the hepatitis B virus (HBV) remains unknown. In the present study, transfection of the HBV genome into human hepatoma cell lines resulted in enhanced expression of ICAM-1 protein and RNA in the absence of inflammation. Results of subgenomic transfections indicated that the HBV X protein (pX) induced ICAM-1 expression. Nuclear run-on assays showed that pX induced the ICAM-1 gene by increasing its rate of transcription. Although both pX and interferon gamma induced transcription of ICAM-1, addition of interferon gamma to cells expressing pX did not show an additive or synergistic effect. These results indicate that pX can directly regulate expression of ICAM-1 and may participate in the immunopathogenesis of HBV infection." @default.
• W2023667108 created "2016-06-24" @default.
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• W2023667108 creator A5041554294 @default.
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• W2023667108 date "1992-12-01" @default.
• W2023667108 modified "2023-10-17" @default.
• W2023667108 title "Up-regulation of intercellular adhesion molecule 1 transcription by hepatitis B virus X protein." @default.
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• W2023667108 doi "https://doi.org/10.1073/pnas.89.23.11441" @default.
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• W2023667108 hasPublicationYear "1992" @default.
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