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- W2023667259 abstract "TGF-J31 were detected immunohistochemically in consecutive paraffinembedded sections from 17 colonic carcino mas, across Dukes A-D stages. In addition, neutrophilic infiltration was assessed in all the carcinomas morphologically and by staining for neutrophil marker, lactoferrin. Areas of obvious ulceration were excluded. Results: All 17 colonic carcinomas expressed FasL. Ten tumors expressed active TGF-J3I, and LAPTGF-J31 was detected in eight tumors. Neutrophilic infiltration was sparse despite widespread FasL expression, or absent even in those that did not express TGF-J31 (n=5). Conclusions: (I ) In contrast to experimental models, FasL expression does not mediate neutrophil recruitment in spontaneous human colonic carcinomas in vivo; (2) the presence of TGF-J31 is variable and not an absolute requirement for prevent ion of neutrophil activation in FasLexpressing human tumors; (3) reports of neutrophil recruitment in experimental allografts or tumors expressing transfected FasL may be related to overexpression of FasL." @default.
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- W2023667259 date "2000-04-01" @default.
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- W2023667259 title "Increased sulphation in oesophageal and gastric carcinogenesis is related to expression of sulpho-Lewisa by mucin and CD44" @default.
- W2023667259 doi "https://doi.org/10.1016/s0016-5085(00)81400-6" @default.
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